KROMOLIN- NATRY (Cromolyn sodium) *.

     Dinatrievaya salt 5 5'- [(2-oksitrimetilen) dioksi bis (-4 - oxo) -4 N-1- benzopiran-2- carboxylic acid], or 5 5'- (2-dinatrievaya salt oksitrimetilendioksi) bis (4 - oxo) -4 H hromen-2- carboxylic acid.

     Synonyms : Intal, Hromoglikat sodium Alecrom, Bicromat, Cromoral, Disodium cromoglycate, Fluvet, Frenal, Inostral, Ifiral, Intal, Introl, Kromolin, Lomudal, Lomupren, Lomusol, Nasmil, Nedocromil sodium, Opticrom, Rynacron, Sodium cromoglicate, Vicrom, Vistacrom, Vividrin and others.

     Kromolin- sodium is a specific tool used in bronchial asthma and bronhospasticheskih state. Underlying it is the ability to inhibit degranulyatsiyu labrotsitov (fat cells), mucous membranes, and respiratory tract delay the release of these substances mediator promoting bronhiolospazma, allergy and inflammation (bradikinina, "slowly reactive substance, and histamine etc.). Perhaps, that the drug is also part of the closure receptors specific mediators of inflammation and holino- and adrenomediatorov limfoidnyh cells. Properties conventional blockers ~ N-receptors kromolin- no sodium.

     Effects of sodium kromolin- evident in the local application by inhalation. If ingestion is no effect.

     Kromolin- sodium is effective in patients with bronchial asthma, and provides warning of the application to the development of bronchial asthma attacks. Continued use of prolonged drug urezhaet and facilitate attacks of asthma, reduces the need for means and bronhorasshiryayuschih corticosteroid. For acute edema drug is not used. Kromolin- sodium most effective in patients with relatively young and have not yet developed chronic changes in the lungs. The operation most expressed in the form of atopic asthma, but the effect is also observed in infectious form of allergic disease, bronchitis with asthma, pnevmoskleroze with attacks asphyxiation, particularly if allergic component.

     The drug used in the form of capsules and powder for inhalation. Each capsule contains 0.02 g (20 mg) kromolin- sodium. Dispersal powder and inhaling produces a special pocket turboingalyatora (Spingaler "), which put the capsule in preparation. Clicking on the top (the cover) pump punctured capsule and powder inhalation enters the respiratory tract. For emptying capsules required four energetic breath.

     Inhalation produce daily. Starting with one of four capsules twice a day intervals 4 to 6 hours In severe cases sometimes increase the dose to eight capsules a day (every 3 hours and 1 capsule). After improving the quantity inhalation gradually, selecting effective dose supportive.

     Kromolin- sodium can be used in combination with bronhorasshiryayuschimi means and corticosteroid. Dose Corticosteroids are usually gradually reduce, and in some cases, completely stop using them.

     Effects of sodium kromolin- develops gradually. The full effect is usually from 2 to 4 weeks from the start of treatment. Treatment should be lengthy. The removal product might resume attacks.

     In applying kromolin- sodium sometimes cough and short bronhiolospazm; Cough assuage reception glasses of water immediately after inhalation, in the case of repeated inhalation bronhiolospazma make pre bronhorasshiryayuschego facility (see Izadrin, Ortsiprenalina sulfate).

     The drug should not appoint women in the first three months of pregnancy and children under the age of 5 years. Prudence (decrease dose) is required in patients with liver and kidney failure.

     Method of issuance : Capsule to 0.02 g (20 mg) in a package of 30 capsules. Applied only for inhalation by special turboingalyatora. If ingestion is not provided.

     The drug is produced in aqueous solution for inhalation in ampoules containing 2 ml of 20 mg sodium kromolin- (Bikromat "capsules for inhalation). Implemented with asthma, with each inhalation should use the new vial; Balance solution applied.

     To handle the inside with food allergies and allergic diseases gastrointestinal tract issued special product formulation hromoglikata sodium called Nalkrom (Nalcrom) capsules of 100 mg (0.1 g). The drug used in the treatment of ulcerative colitis. Assign inside adults to 0.2 grams (2 capsules) four times a day for 20 to 30 minutes food. The children, ages 2-14 years appoint one capsule four times a day. Gradually reduce the number of doses (up to 0.3 0 adults , 2 g / day). The course of treatment lasts from 2 to 3 weeks to 2 to 3 months or more.

     Is in the form of capsules. You can also mixture content capsules in a cup, add 1 teaspoon hot water and dining spoon cold boiled water and drink '.

     The so-called "Lomusol (Lomusol) issued hromoglikata 2% solution of sodium in the form of aerosol (spray) for the treatment and prevention of allergies rinitov.

     Available in cans containing 26 mg of solution.

     Producing one injection every bow at 4-6 times a day.

     Bikromat aerosol (In icromat on sol y r) is produced in bottles of 15 ml. Contains 200 kromolin- single dose of sodium and 1 mg dose.

     For use in ophthalmology practice of acute and chronic allergic conjunctivitis and seasonal keratokonyunktivitah produced 2% aqueous solution of sodium hromoglikata called "Optikrom (O pticrom A qu e ous) and Bikromat- Kollir" (In icromat- So llyr e). Pipes 1 - 2 drops in each eye 3 - 4 times a day.

     Open a bottle remain in a cool place no more than 1 month.

     Combined preparation containing sodium kromolin- and b-adrenostimulyator fenoterol (see), published abroad under the name "Ditek (Dit eU) *. By kromolin- of sodium is added, thus bronhorasshiryayuschee of simpatomimetika (see also Berodual).

     The drug appears as doziruemogo aerosol bottles of 10 ml, containing 200 single doses. A dose of 1 mg sodium kromolin- and 0.05 mg fenoterola (hydrobromide).

     Preparation is the most effective in patients with atopic asthma form.

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