KORTIKOTROPIN (Corticotropinum).

     Synonyms : Adrenocorticotropic hormone AKTG, Acethrophan, ACTH, Acthar-Acton, Actrope, Adrenocorticotrophin, Cibathen, Corticotrophinum, Cortrophin, Exacthin, Hormonum adrenocorticotropinum, Solanthyl.

     Hormone formed bazofilnyh front of pituitary cells. For medical applications from the glands of cattle, pigs and sheep kortikotropin injection (Corticotropinum pro injectionibus). Available in glass, sealed in a sterile vials of dried powder white or nearly white, slightly soluble in water. The solution for injection are ex tempore dissolved powder (in aseptic conditions) in sterile isotonic sodium chloride solution.

     Kortikotropin is a polypeptide hormone consisting of 39 amino acids. Its activity is defined by biological and expressed in action (ED).

     Kortinotropin is a physiological stimulus adrenal cortex. He is increased biosynthesis and release current blood corticosteroid hormones, mainly glucocorticoids (cortisol, cortizone, etc.) as well as androgenov. Every content in adrenal ascorbic acid, cholesterol.

     Between kortikotropina allocation from the front portion of pituitary and adrenal cortex hormones in the blood is strong. Increased allocation kortikotropina begins in the fall of corticosteroid in the blood and is hampered when its corticosteroid raised to a certain level.

     Clinical Effects kortikotropina similar to actions glucocorticosteroids. It has anti-inflammatory and antiallergic has immunodepressivnoy activity is the connective tissue atrophy affects carbohydrate; Protein exchange and other biochemical processes.

     Earlier kortikotropin widely used to treat rheumatoid arthritis, infectious nonspecific poliartritov, asthma, acute leukemia limfoblastnogo and mieloblastnogo, neyrodermita, eczema, allergies and various other diseases. Currently, for these purposes are normally applied glucocorticoids, as well as steroidal drugs (anti, protivogistaminnye and antiallergic drugs, etc.).

     Basically kortikotropin used in secondary hypothyreosis adrenal cortex, in order to prevent wasting glands and Development <syndrome lifting> after lengthy treatment corticosteroid drugs. However kortikotropin continues to be effective treatment for these diseases.

     Kortikotropin also used for the study of functional gipotalamo- gipofizarno- nadpochechnikovoy system.

     Enter kortikotropin usually in the muscles. When administered medication ineffective, as the enzyme destroys the gastrointestinal tract. With the muscles, it is rapidly absorbed. Effects of single dose lasts in giving muscle 6 to 8 hours, so the injection repeat 3 to 4 times daily.

     In rare cases, to obtain a rapid and more powerful effect permitted intravenous drip kortikotropina a solution, for which preparation plants in 500 ml isotonic sodium chloride solution.

     For therapeutic purposes, depending on the severity of the disease are on 10-20 ED kortikotropina 3 to 4 times a day for 2 to 3 weeks. By the end of treatment reduces the dose to 20 - 30 ED day. When introducing children to reduce the dose of 2 to 4 times depending on age.

     If necessary kortikotropinom treatment can be repeated.

     For diagnostic purposes introduce one drug dose 20-40 ED.

     The effectiveness of treatment is to be measured over the disease and clinical development of corticosteroid in the blood and urine.

     Prolonged continuous use kortikotropina for therapeutic purposes is impractical because can cause adrenal cortex.

     Using kortikotropina (especially with the introduction of large doses long) can be side effects : a tendency to delay in the body of water, sodium and chlorine ions with the development of oedema and improve blood pressure, tachycardia, the excessive increase, Protein Metabolism negative nitrogen balance, initiation, insomnia , and other violations of the central nervous system, a moderate girsutizm, menstrual irregularities. There may be a delay scarring wounds and mucous membranes, pitting the gastrointestinal tract, increasing hidden pockets of infection; Children-growth inhibition. There phenomenon diabetes, and with the available diabetes-enhancing giperglikemii and ketoz, and the allergic reaction that requires removal from the market.

     Kortikotropin is not suitable for serious forms of hypertension and disease Itsenko - Kushinga, pregnancy, circulatory failure III stage acute endocarditis, psychosis, nephrite, osteoporosis, stomach ulcers and duodenal ulcers, after recent surgery, and syphilis, and the active form of tuberculosis (unless specific treatment), diabetes, allergies to kortikotropin in history.

     Product : in the hermetically ukuporennyh bottles with cork and rubber-metal phase containing 10-20-30-40 kortikotropina ED.

     Storage : List B. In dry, the dark place at a temperature no higher than  +20 C.

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