KORAZOL (Corazolum) 1, 5-Pentametilentetrazol.

     Synonyms : Angiazol, Cardiazol, Centrazol, Deumacar, Diovascol, Leptazol, Metrazol, Pentamethazolum, Pentazol, Pentetrazolum, Pentrazol, Pentylentetrazol, Phrenazole, Tetracor and others.

     The white crystalline powder. Very easily soluble in water and alcohol. Aqueous solutions (H p 6 - 8 0, 0) + 100 sterilized with C for 30 min.

     Has the incident effect on the respiratory and sosudodvigatelny points. Initiation breathing, increased blood pressure and improve blood circulation especially expressed, if these centres are suffering brain distraught. Direct effects on the heart and vascular medicine will not help.

     In high doses, causes stir the brain and spinal cord and can have <<WAKE>> effect in acute poisoning by drugs and narcotics. In high doses korazol also convulsant effects associated primarily with the effects of brain motor area and only partly to the influence of the spinal cord.

     Last korazol widely used to shock, asphyxiation, weakening the heart during surgical interventions, as well as the poisoning of drugs, drugs, analgetikami.

     In psychiatric practice used korazolom convulsant medication for schizophrenia.

     Recently, the use corazolum (and other analeptikov) in the poisoning of drugs were considered unsuitable because it increases the brain needs oxygen. In addition, more specific way to barbiturate poisoning and other means to narcosis is Bemegride (see). When drug poisoning analgetikami have enjoyed - specific antagonist naloxone (see).

     In psychiatric practice currently korazol also does not apply.

     Therefore korazol excluded from the range of medicines.

     However korazol remains a very valuable tool for experimental pharmaceutical research. They are widely used in finding and exploring convulsants and other neuro (psychotropic) psychotropic drugs.

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