KOKAIN (Cocainum).

     Alkaloid, soderzhashiysya leaves South American plants (bush) E rythroxylon coca.

     In clinical practice using cocaine hydrochloride (Sosa ini hydro chloridum).

     Synonym : Cocainum hydrochloricum.

     Benzoilekgonina methyl ester hydrochloride.

     Clear crystal ball or white crystalline powder bitter taste, causing concern with the language in the sense of feeling. Very easily soluble in water (2:1), easy-to alcohol (1:2, 6). Aqueous solutions are sterilized tindalizatsiey. The stabilization solutions adds solution of hydrochloric acid (HCl) to pH 3, 5, 4, 0.

     Cocaine is the first natural compound, which found mestnoanesteziruyuschaya activity, an ability to reduce or completely suppress sensitive nerve excitability okonchanny and hinder initiation of a nerve fibers. Later received a large number of synthetic substances with a similar activity.

     Cocaine along with the action on sensitive nerve roots had expressed influence on the central nervous system.

     When intake, it can cause euphoria, stir, then the oppression of CNS. With long as a violation nervous system, gastrointestinal, cardiovascular, respiratory; The pain of addiction can develop (kokainizm).

     Currently, because of the high toxicity of cocaine use is limited. They are only occasionally as superficial anestetikom for local anaesthesia konyunktivy and cornea (1 - 3% solution), mucous membranes of the mouth, nose, larynx (2 - 5%), pulp anesthesia for a tooth. Cocaine raises and maybe sluschivanie cornea epithelium. Sometimes, especially in the elderly, under the influence of cocaine could experience more inner pressure and acute glaucoma attack. It should also be borne in mind that the introduction of the bag and causing konyunktivalny to mucous membranes of the mouth, nose, etc. cocaine absorbed and can cause the phenomenon of intoxication. Particular caution should be exercised in applying the drug for anesthesia respiratory tract with tomography.

     To reduce the intake of cocaine and lengthening his actions to his usual solutions typically adds solution via (5 ml cocaine 3 to 5 drops of 0.1% solution of epinephrine hydrochloride).

     In connection with the potential to cause narrowing of vessels in the area of cocaine (at concentrations 0.2-1 - 2%) in the past included in the drops and ointments used to treat rinitov, conjunctivitis.

     In recent years, the high potential cocaine drugs for these purposes little use.

     Higher doses for adults (single and daily) 0.03 g.

     Product : powder.

     Storage : A. In a list ukuporennyh banks orange glass in the dark spot.

     Sold restrictions as other drugs.

     Medicines containing cocaine, released only in the hands of doctors.

Materials allowed to copy only with the active hyperlink to the handbook of medicines