KOBAMAMID (Cobamamidum).

     For a [a - (5, 6 dimetilbenzimidazolil) - So b-adenozilkobamid.

     Synonyms : Adenozilkobalamin, Adenosylcobalamin, Cobamamidum dibencozide, Coenzym B12.

     Dark red crystalline powder. Gigroskopichen. Mg in the water; Almost nerastvorim of alcohol.

     Kobamamid chemically different from tsianokobalamina that the cobalt atom covalent bond is not connected with tsianogruppoy, and b -5 '- dezoksiadenozilnym balance.

     Kobamamid is kofermentnoy form of vitamin In 1912, ie one which should become tsianokobalamin to provide inherent physiological (and health) effects.

     Like tsianokobalaminu kobamamid involved in a number of biochemical reactions, the body's life support (in the transfer of methyl groups in the synthesis of nucleic acid, protein, amino acids, in exchange, carbohydrates, lipids, etc.). Provides treatment effect not only in the 12-scarce anemia, but also with the nervous system disease, wasting processes and other drug has anabolic activity.

     Applied as anabolic means babies with low weight and malnutrition problems, young children with impaired appetite and weight, adults with the syndrome nervous anorexia and fatigue. Also used in the peripheral nervous system diseases (disease, traumatic injury, etc.); In 12 short of anemia in adjuvant therapy of liver disease (chronic hepatitis, cirrhosis, muscular dystrophy), chronic enterocolitis, etc.

     Kobamamid enter into or parenteral (intramuscularly, subcutaneously, intravenously).

     Children inside appoint 0.0002 g (200 µ g), 0.0005 g (500 µ g) 2 - 5 times a day (half an hour before eating). For ease of dissolving tablet (without skin) in 5% glucose solution or boiled water (25-50 ml). Dose adult-0.0005 - 0.001 g-1 6 times a day. The course of treatment typically lasts seven to 30 days.

     Children injected intramuscularly, or one day for every 0.0005 g injections; Treatment 7 - 10 days.

     Adults with nervous syndrome anorexia and fatigue designate the interior of 0.0005 - 0.001 g 3 to 6 times a day (daily intake to 0,003 grams). The course of treatment for 1 to 3 months.

     In the peripheral nervous system diseases, in the 12-scarce anemia, chronic lymphoblastic impose intramuscularly to 0,0005 0,001 grams (500 to 1000 µ g) 1 times a day every day for a month, or 0.0005 - 0.0015 g through day (at 12-scarce anemia). The course of treatment 20-ZO injection. If necessary, through Feb. 6-month course again.

     In the treatment of chronic hepatitis, fat dystrophy liver cirrhosis, chronic pancreatitis and enterokolitov designate kobamamid intramuscularly in dose-0.00025 0.0005 g (250-500 µ g) 1 per day 3 days; In the course of 10 - 15 inektsny.

     There is evidence of the effectiveness of adjuvant therapy kobamamida inflammatory lesions and dystrophic attack.

     Method of issuance : pills to 0.0005 and 0.001 g (without coating) svetlorozovogo color; Pills to 0.0001; 0.0005 and 0.001 g-coated (white respectively; Brown and pink-brown color); Smallpox the powder in capsules (for injection) to 0.0001; 0.0005 and 0.001 g (100; 500 and 1000 µ g) for 5 vials complete with five ampoules of water for injection of 2 ml.

     Storage : dry, the dark spot.

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