Co trimoksazol (co-trimoxazolum)


IHP TRIMOKSAZOL (Co-trimoxazolum).
     Combined preparation containing two active substances : sulfanilamidny product and product diaminopirimidina sulfamethoxazole - trimethoprim.
     Synonyms : Apo- Sulfatrim, Baktekod, Baktoredukt, Baktrim, Berlotsid, Bikotrim, Biseptol, Bisutrim, Kyung Ultrazol, Groseptol, Duo- Septol, Intrim, Cotrim, Kotrimoksazol, Kotrimol, Kotrifarm, Novo Trimel, Oribakt, Oriprim, Septrin, Sinersul, Sulotrim, Sulfametoksazol and Trimetoprim, Sulfatrim, Sumetrolim, TMS 480, Trim, Trimezol, Trimosul, Tsiplin, Ekspozol, Abactin, Abactrim, Andoprim, Aposulfatrim, Apo-Sulfatrim, Bactecod, Bactramin, Bacterial, Bactrimel, Bactrisol, Bacticel, Bactofer , Bactoreduct, Bactrim, Berlocid, Bicotrim, Biseptol, Bisutrim, Chemitrin, Ciplin, Cotrim, Cotrimol, Cotrimoxazol, Cotripharm, Doctonil, Duo-Septol, Ectapprim, Espectrin, Expozol, Falprin, Gantrin, Gen-Ultrazol, Groseptol, Infectrim, Intrim , Metomide, Microcetim, Nolapse, Novo-Trimel, Oradin, Oribact, Oriprim, Potesept, Primazol, Rancotrim, Resprim, Septocid, Septrin, Sinersul, Sulotrim, Sumetrolim, TMS 480, Trim, Sulfamethoxazole and Trimethoprim, Trimexazol, Trimezol, Trimosul, Trixazol, Uroxen, Vanadyl and others.
     Sulfamethoxazole (Sulfamethoxazolum). 3-(para-Aminobenzolsulfamido) -5 - metilizoksazol.
     Synonyms : Gantanol, Metoxal, Radonil, Sunomin, Sulfamethoxazole, Sulfamethylisoxazole, Sulfisomezole, Sulphamethoxazole.
     Is antibacterial drug, similar to other chemotherapeutic activity sulfanilamidnymi drugs.
     Trimethoprim (Trimethoprimum). 2, 4-Diamino-5- (3, 4, 5-trimetoksibenzil) - Pyrimidine.
     Synonyms : Metopicide, Syraprim, Trimethoprim.
     In Gliwice-fascist structure close to hloridinu (see). Antibacterial activity.
     The combination of these two drugs, each of which has a bacteriostatic effect, provides high bactericidal activity against gram and gram microorganisms, including bacteria resistant to sulfanilamidnym drugs.
     Bactericidal effects of double baktrima blocking action on the metabolism of bacteria. Сульфаметоксазол нарушает биосинтез дигидрофолиевой кислоты, а триметоприм блокирует следующую стадию метаболизма - восстановление дигидрофолиевой кислоты в необходимую для развития микроорганизмов тетрагидрофолиевую кислоту. Choosing sulfamethoxazole as a component baktrima due to the fact that he has the same speed off with trimethoprim.
     The drug is available in two dosages of tablets : for adults with a 0.4 g tablets (400 mg), sulfamethoxazole and 0.08 g (80 mg) trimethoprim; For children with one 100 mg tablet 20 mg sulfamethoxazole and trimethoprim.
     Adults also produces tablets <<Baktrim Fort>> containing 800 mg 160 mg sulfamethoxazole and trimethoprim, a syrup for children, in 1 ml of a 40 mg and 8 mg sulfamethoxazole trimethoprim (suspension white with a yellowish sheen color in vials 100 ml).
     The drug is effective against streptococcal staphylococcus, pneumococcal, wand dysentery, typhoid, intestinal bacillus, Protea; Ineffective against Mycobacteria tuberculosis, spirohet, Bluepus wand.
     The drug is rapidly absorbed by ingestion. The maximum concentration in the blood was 1 to 3 h after admission and continued for 7 hours High concentrations established in the lungs and kidneys. There were a large number of urine (in a 24-hour out of 40-50% trimethoprim and sulfamethoxazole about 60%, mainly in the form atsetilirovannoy).
     Baktrim effective for respiratory tract infections (acute and chronic bronchitis, empyema pleura, bronhoektaticheskaya disease Abscess lung pneumonia), the urinary tract (urethritis, cystitis, pielity, chronic pyelonephritis, prostate, gonokokkovy get). Applied also in the gastrointestinal tract infections, surgical infections and other infectious diseases. The drug is also effective in septicemia caused by bacteria susceptible to the drug. A high efficiency in the preparation of uncomplicated gonorrhea.
     Assign inside, adults and children older than 12 years are usually two pills (for adults) two times a day (morning and evening after eating); In severe cases, appoint two tablets three times a day; Chronic infection-1 pill 2 every day. Children aged 2 to 5 years, usually for two tablets for children two times a day, ranging from 5 to 12 years - to 4 tablets for children 2 times a day. The course of treatment lasts from 5 to 12 to 14 days, a chronic disease it longer, depending on the period of illness.
     Baktrim an active antibacterial drug, but may cause some side effects. There are nausea, vomiting, diarrhea, allergic reactions, nephropathy.
     Could develop radiation and agranulotsitoz.
     The drug should be used under close medical supervision.
     Contraindications : Hypersensitivity to sulfanilamidam, disease haematopoietic system, as a violation of liver and kidney pregnancy. The drug should not appoint premature and newborn children. In baktrim caution should be used in young children. In drug treatment, care must be taken pictures of blood.
     Product : tablets in a package of 20 pieces.
     Storage : List B.
     In Poland, issued under the name <Biseptol 480>.
     Produced in Hungary preparation <<Poteseptil>> contains trimethoprim and superseptil (ie sulfadimezin) instead sulfamethoxazole. Doses are the same as in baktrime, ie for adults in pill contains 400 mg and 80 mg sulfadimezina trimethoprim.
     Close on the composition of foreign drugs produced also called <> (Groseptol Groseptol) <> (Ditrim Ditrim) and others.
     Evidence dose and contraindications to the use of these drugs are the same as for baktrima.

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