KLORAZEPAT (Clorazepate).

     Complex compound potassium salt 7-chloro-2 - 3 digidro-2- okso-5- phenyl-1 H-1, 4-benzodiazepinkarbonovoy acid with potassium sarcastic.

     Synonyms: Apo- Klorazepat, Tranksen, Apo-Chlorazepate, Tranxen.

     Light yellow powder, well soluble in water, nerastvorim in organic solvents.

     He has a strong anksioliticheskoy (antifobicheskoy) activity and expressed little miorelaksantnym, sleeping and sedative effects.

     Refers to the so-called "day" tranquilizers.

     When you receive inside absorbed rapidly and almost completely, with max of 45-60 min, T 1 / 2 to 2 days; Being in the liver biotransformation education nordiazepama devoted kidneys.

     Apply in alarming condition, increased excitability, in partial epileptic seizures, and to prevent deliriya in chronic alcoholism.

     Assign an adult on the inside 0,015-0,03 g (15-30 mg) per day (g 0,005-0,01 for an appointment), may increase the dose to 0.06 g (60 mg) a day, while acute alcohol intoxication in the first day to 0.09 g (90 mg) a day. Older patients and weakened appoint overnight 0.00375 (3.75 mg), children - 0.5 mg / kg in some cases.

     Possible side effects: headaches, memory violation, ataxia, diplopia, paradoxical reaction type of aggressiveness and irritability, dispersion, arterial hypotension, lower hematocrit and others.

     The product contraindications with respiratory distress and children up to age 9.

     Muscle, barbiturates, adjunct, for anaesthesia and alcohol increase (each) klorazepata effects.

     The specific antagonist flumazenil is (see).

     Form release: capsules to 0.00375; 0.005 and 0.01 g (3.75; 5 and 10 mg).

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