KLONIDIN (Clonidine)

     Chemical name : 2,6 - Dihlor-N-2- imidazolidinilidenbenzamin (and as hydrochloride)

     Description : The white crystalline powder. Mg in the water, poorly soluble in alcohol, ether and chloroform.

     Pharmacology : drugs, anti-hypertensive effect, sedative.

Institute alfa2- adrenoretseptory lowering the tone sosudodvigatelnogo centre suffering brain and reduces impulsatsiyu in the sympathetic chain peripheral nervous system presinapticheskom level. Well absorbed from the digestive tract. The maximum effect is evolving within 2-4 h, and remained about 5 hours Duration is from 6 to 12 h. T1 / 2 to 12 h. Easily permeates through GEB. Write mainly kidneys unchanged. Lowers OPSS, CHSS, Cardiac Output. Decreases inner liquid products and improves its outflow reduces inner pressure. The prolonged delay by water in the body. With the rapid introduction of AD may briefly increase for the stimulation of peripheral adrenoreceptor.

     Application : Hypertensive crises, arterial hypertension, acute myocardial infarction in the period (in the absence of kardiogennogo shock and the attendant increase AD), the primary otkrytougolnaya glaucoma, high - and middle-inner pressure, the withdrawal syndrome drug abuse (in the adjuvant therapy).

     Contraindications : Giperchuvstvitelnost, kardiogenny shock, arterial hypotension, peripheral artery disease obliteriruyuschie, AV blockade II-III extent, the weakness sinusnogo node syndrome, depressive moods.

     Restrictions on the use : Pregnancy, breast-feeding; Work related to the need for quick mental or physical reaction.

     Side Effects : Suhost mouth, constipation, weakness, drowsiness.

     Networking : Gipotenzivny effect weakens Nifedipine. When applying to Neuroleptics are synergies of sedation can be expressed depressive disorders.

     Overdosing : Symptoms : violation of consciousness, collapse to an acute poisoning is aetiology, R QRS complex, possibly slower AV conduction and early repolyarizatsii syndrome.

Treatment : symptoms.

     Dosing and Administration : inside, parenteral instillyatsii in the eye (drops). Dose and design individual treatment.

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