KLONAZEPAM (Clonazepamum). 7 - Nitro-2 - 3 digidro-5- (ortho-chlorophenyl) -1 H-1, 4-benzodiazepin-2- it.

     Synonyms : Antelepsin, Antelepsin, Clonazepan, Clonopin, Iktoril, Iktorivil, Ravatril, Ravotril, Rivatril, Rivotril, etc.

     Clonazepam similar in structure to nitraeepamu (see), which is only a chlorine atom in the position of the phenyl 2 kernel.

     Like tranquilizers group dibenzoazepina, clonazepam have a calming, relaxing muscle, acid and protivosudorozhnoe effect. Protivosudorozhnoe effect of clonazepam was stronger than the other drugs in this group, and therefore its use primarily for the treatment of convulsions states. For epilepsy patients taking clonazepam, a stroke less and less intensity.

     The drug is rapidly absorbed. Once inside peak concentration in plasma observed in 1 - 2 hours

     The drug has long. Half of organnzme 18 - 20 h. Write in with the urine.

     Applied clonazepam in children and adults with small and large forms of epilepsy with mioklonicheskimi attacks, and psychomotor crises, high myshechom tone. Using as a relief, especially in patients with organic brain damage.

     Treatment clonazepam start with small doses, gradually increasing them to obtain optimal effect. Dosage individual, depending on the patient and his reaction to the drug. The agent designated in one dose, 5 mg a day, divided into three installments. Gradually increase the dose of 0.5 to 1 mg every third day to get a synergistic effect. Usually appoint 4 to 8 mg per day. Do not exceed the recommended dose of 20 mg per day.

     Children clonazepam designate in the following doses : infants and children up to 1 year-0.1 to 1 mg per day, from 1 to 5 years - 1, 5, 3 mg a day, from 6 to 16 years 3 to 6 mg of day. The daily dose divided into three installments.

     Before the drug can coordinate movement disorder, irritability, depression phenomenon, increased fatigue, nausea. To reduce the side effects must individually find the optimal dose, beginning with smaller doses and gradually increasing.

     Contraindications and precautions are the same as for other benzodiazepines (see).

     The drug crosses the placental barrier and in breast milk. His appointment should not be pregnant and lactation period.

     Product : pills to 0,001 g (1 mg) in a package of 30 or 50 pieces.

     Storage : List B.

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