KLOMIFENTSITRAT (Clomiphen citras). 1-[4 - (2-Dietilaminoetoksi) phenyl] -1, 2-Diphenyl hloretilena citrate.

     Synonyms : Klostilbegit, Ardomon, Chloramiphene, Clomid, Clomifeni citras, Clomivid, Clostilbergyt, Dyneric, Fertilin, Fertomid, Genozym, Gravosan, Nefimol, Omifin, Pergolime, Prolifen, Serofen and others.

     White or white with a white crystalline powder kremovatym little soluble in water, soluble in alcohol moderately.

     The drug is a mixture of cis-and trans forms of the compounds; More active cis-isomer, and its content in the preparation of at least 50%.

     On chemical structure relatives hlortrianizenu (see), a drug that has the oestrogenic activity, and tamoxifen (antiestrogennomu preparation).

     Klomifentsitrat belongs to the group of drugs called antiestrogenami. Drugs in this group specifically associated with estrogenozavisimymi receptors (estrogen receptor) in the hypothalamus and ovaries. In small doses, they increased secretion gonadotropinov (prolactin, and follikulostimuliruyuschego lyuteiniziruyuschego hormones) and stimulate ovulation. At the small content of endogenous estrogen in the body, these drugs have been moderate oestrogenic effect, but with a high level of estrogen they have antiestrogennoe effect. By reducing the level of circulating estrogen (oppressive in large concentrations gonadotropnyh secretion of hormones), they increase gonadotropinov secretions. In high doses, these drugs can inhibit the secretion gonadotropinov. Gestagennoy androgennoy activity and they do not possess.

     In connection with these properties klomifentsitrat appropriate doses used as a means of stimulating ovulation in anovulyatornoy ovarian dysfunction and related infertility, and dysfunctional uterine krovotecheniyah, disgonadotropnyh forms of amenorrhea and other disorders associated with endocrine violations ovulation.

     Applied also klomifentsitrat with breast cancer.

     Because of the stimulation secretions gonadotropinov also used in klomifentsitrat androgennoy failure oligospermii men and the delay of sexual and physical development of young males.

     Using diagnostic violations gonadotropnoy pituitary function.

     Klomifentsitrat can be used in combination with drugs gonadotropnyh hormones. It is well absorbed when administered slowly out from the body; During polususchestvovaniya drug in the body is 5 to 7 days.

     Is klomifentsitrat inside (regardless of meal times).

     To stimulate ovulation appointed interior dose of 50 mg (0.05 g) 1 once a day (at night), starting with the 5-day menstrual cycle, over five days.

     Pre-determine the estrogen in the body. In the absence of effective treatment for repeat, with 3 to 5 courses, increasing the daily dose of 75 to 100 mg or increasing the rate to 10 days. Heading dose of a drug that should not be more than 500 mg.

     When disseminated breast cancer (a woman in menopause is not less than 1 year) designate 100 mg 2 times a day (morning and evening) daily for a long time. If the disease treatment ceased.

     In treatment klomifentsitratom continued monitoring gynaecologist should check ovarian function, the study of vaginal, watch phenomenon <maybe> and others should be generally careful monitoring of the patient.

     Klomifentsitrat is very effective inducer of ovulation, but it may cause some side effects. The most dangerous complication is giperstimulyatsiya ovaries, which have pain in the lower abdomen, in flatulence, menorragii; Increasing the size of the ovaries by the sharp increase of estrogen in the body (an increase kariopiknoticheskogo index more than 70% to 80% and estrogen excretion above 200 µ g / day).

     Men klomifentsitrat appoint 50 mg 1 to 2 times a day for 3 to 4 months of systematic control of scarcity. When treating pain medication may be in eggs.

     Teenagers, delayed sexual and physical appoint 50-100 mg / day (depending on body weight) courses for 10 days; All three courses at intervals 1 - 3 months.

     In applying klomifentsitrata possible nausea, diarrhea, tidal blood-to-face, dizziness, allergies Medicine, psihasteniya, embolic complications, visual impairment.

     Klomifentsitrat contraindicated in pregnancy, malignant and benign tumors, organic central nervous system diseases, liver disease, krovotecheniyah (not involving a breach of ovulation), a propensity to tromboobrazovaniyu.

     The emergence of giperstimulyatsii ovarian and common side effects require dose reduction or withdrawal of the drug.

     Nor should appoint preparation (for outpatient care) persons whose work requires quick mental and physical reactions.

     Product : pills to 0.05 g (50 mg) to 30 pieces in a glass lighting banks.

     Storage : List B. In the dark spot.

Materials allowed to copy only with the active hyperlink to the handbook of medicines