KLOFIBRAT (Clofibratum) *.

     Ethyl a - (para-hlorfenoksi) - isobutyrate.

     Synonyms : Atromidin, Klofibreyt, Lipomid, Miskleron, Acolestol, Amadol, Amotril, Antilipid, Arterioflexin, Atemarol, Ateriosan, Aterosol, Athebrate, Atheromide, Atosterine, Atrolen, Atromid S Atromidin, Chlorophenisate, Clofibrat, Clofibril, Clofibrin, Clominon, Corafen , Fibramid, Geromid, Hypocerol, Klofibrat, Lipavil, Lipavlon, Lipomid, Liponorm, Lisisterol, Miscleron, Neo-Atromid, Nibratol, Normolipol, Regelan, Sterochol and others.

     Light yellow liquid with low aromatic smell. Nerastvorim in water, soluble in alcohol, ether and other organic solvents.

     Klofibrat was the first drug of the group fibroevoy acid derivatives (fibratov), which has been used as lipid funds. Currently, several fibroevoy acid derivative (see Bezafibrat, Fenofibrat etc.).

     Drugs piece group is lowering cholesterol and triglycerides in the blood plasma, in triglycerides and cholesterol LPONP LPNP. However, they raise the level of cholesterol in LPVP (antiaterogennyh).

     Reducing cholesterol is linked to fibratov block reduktazu gidroksimetilglutarovogo kofermenta A (NM G SoA) involved in the biosynthesis of cholesterol, and increase the breakdown of cholesterol.

     Fibraty also reduce the aggregation of blood platelets and viscosity. Reduces levels of uric acid in blood plasma. In order to prevent these drugs used in the family NCEP, Moyle and gipertriglitseridemii, idiopathic lower maintenance engineers.

     As the therapeutic use of combination therapy with coronary atherosclerosis and peripheral vascular vessels brain, angiopatii diabetes and retinopathy, diseases, soprovozhdayushihsya hyperlipidaemia, including Moyle, coupled with the rising level of uric acid in blood plasma.

     Drugs group fibratov differ on the effectiveness and transferability. For example, klofibrat slightly less efficient than the new drugs (bezafibrat, fenofibrat) of this group, and is more side effects.

     Klofibrat designate inside capsules containing 0.25 to 0.5 g. Adopt - 0.75 g (2 - 3 capsules), 3 times a day (after eating). Treatment usually hold courses for 20 - 30 days with the same interruptions (4-6 courses).

     In applying fibratov possible gastrointestinal disorders (nausea, vomiting), skin itch, urticaria, pain in muscles (such GACVS), muscle weakness (in the bowl leg); The increase in body weight because of the delay of water in the body. When the drugs are usually those phenomena.

     With long-term use klofibrata and other fibratov can develop vnutripechenochny cholestasis, worse zhelchnokamennaya disease. In the application, there klofibrata education stones in gall bladder and biliary tract (and therefore in some countries stopped using the drug).

     Fibraty increase of anti kumarinovyh, butadiona, salitsilatov, oral antidiabetics drugs. They are in patients with diabetes should be treated with caution to avoid hypoglycemia.

     Klofibrat and other fibraty not receive liver disease, severe kidney disease, pregnancy and lactation. Do not assign these drugs to children.

     Product : capsules of 0.25 and 0.5 g.

     Storage : Keep in a cool place.

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