TSISPLATIN (cisplatin).

     Cis - Diamindihlorplatina (II).

     Crystalline powder from yellow to yellow-orange. Slowly, and very few soluble in water and isotonic sodium chloride solution.

     Synonyms: Platidiam, Platidiam, Platinol.

     Is integrated MMDBA platinum compounds with antitumor activity. Good is a cis-isomer; Trans-isomer activity is not. Figure II means basicity (valence) of platinum.

     The mechanism of antitumor drugs (and other derivatives platinum) is the ability to bifunktsionalnomu density DNA fibres, leading to prolonged pain suppression of nucleic acids and cell death. The ability of the drug to cause regression of primary tumors and metastasis was also influenced by the body's immune system.

     Tsisplatin ineffective admission inside. With the introduction of intravenous quickly and in large numbers comes in the kidneys, gastrointestinal tract, liver, Ovary; Discovered in the skin, muscle, bone. After not cross the blood-brain barrier penetrating. A significant number (90%) associated with plasma proteins. Slowly kidneys available: small quantities in the hours and 40% after 5-day introduction.

     Tsisplatin apply separately or integrated therapy (in combination with metotreksatom, tsiklofosfanom, tioguaninom, protivoopuholevymi protivoopuholevymi antibiotics and other drugs) in malignant tumors and cell ovarian, cervical cancer, bladder, in ploskokletochnom cancer of the head and neck, with osteogennoy sarcoma. Apply in integrated therapy infection and lymphosarcoma.

     Enter tsisplatina solution intravenously. In monohimioterapii usually imposed at the rate of 20 mg / m 2 1 surface of the body daily for 5 days or Z0 mg / m 2 1 day to 3 days, or 100-150 m 2 to 1 m 2 1 every 3 weeks . The interval between courses 3 weeks. The total number of courses defined individually.

     To dissolve drug injection at the rate of 10 mg dry 10 ml of sterile water for injection and the solution razvodyat in 1 L isotonic sodium chloride solution, or 5% glucose solution.

     Solution impose struyno (slowly), or as a long Infusion (in the 6-48 h).

     To reduce patients, it is recommended prior to the introduction tsisplatina hydrate the body sick, giving a 8 - 12 p 1 - 2 or isotonic sodium chloride solution, or 5% glucose solution.

     In applying tsisplatina possible violations, kidney function, nausea, vomiting, loss of appetite, dizziness, noises in the ears, demotion hearing anafilakticheskie reaction, leukopenia, thrombocytopenia, anemia. There neuropathy Most affected nerves lower limbs (especially nerves ikronozhnyh muscles)

     Perhaps a pain in the course of a vein after the intravenous drug. The product contraindications for violations, kidney and liver functions, blood kostnomozgovogo oppression, circulatory failure, gastric ulcer disease and stomach cancer, pregnancy and individual intolerance,

     During the treatment must be systematically studied kidney function (as defined protein content, kreatinina, urea, uric acid), to conduct blood tests, to audiometriyu.

     It should not be combined with the use tsisplatina drugs, or have nefro- ototoksicheskoe influence (antibiotiki- aminoglycosides, streptomycin etc.).

     Form release: tsisplatin sufficient to 0.01 g injection (Cisplatinum lyophilisatum 0.01 pro inj tionibus EU) in the ampoule in the package of 10 vials. It is a porous mass of a light yellow colour variations; Easy falls in powder.

     Storage: List A. sheltered from the world scene with a temperature higher than  + 10C.

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