TSINNARIZIN (Cinnarizine) *. trans-1- Tsinnamoil-4- difenilmetil- piperazine or N-benzgidril-N'- transtsinnamoil- piperazine.

     Synonyms: Stugeron, Cinniprine, Dimitronal, Glamil, Labyrin, Marisan, Midronal, Mitronal, Stugeron, Stutgeron and others.

     Tsinnarizin positively affect the brain, peripheral and coronary circulation: improves microcirculation. Improves ability to cell deformation and reduces high blood viscosity. Increases resistance to hypoxy tissue.

     The product has a direct effect on skin blood vessels, reducing their response to nutrient substances sosudosuzhivayuschie (Angiotensin etc.). Potentsiruet effect on the brain vessels SO. At AD system, the frequency of cardiac reductions sokratimost and conductivity heart is not affected.

     The product has also protivogistaminnoy activity. Less anxiety vestibular apparatus (suppresses association).

     In modern data pharmacological properties tsinnarizina largely due to its ability to block the membrane calcium channels (see Antagonisty calcium ions). It inhibited the flow of calcium ions into cells and reduces them to depots plazmolemm (sarkolemm).

     The product is well absorbed. When you receive inside peak concentration in blood plasma through a 1 - 3 h; Half-time 4 hours Actively product. A third is allocated to the metabolites in urine, and 2 / 3 of cal.

     Tsinnarizin apply to violations of brain and peripheral blood, vestibular disorders. Despite protivogistaminnoy activity, specifically as a means protivogistaminnogo not used because of better drugs (see Gistamin and inexpensive drugs).

     As tserebrovaskulyarnoe funds designated for violations of brain circulation associated with vascular spasm, atherosclerosis, carried skull brain injuries, stroke. The product reduces tserebroastenicheskie phenomenon, headache, noise in the ears, the general condition improves.

     Assign tsinnarizin with migraine, disease Menera.

     Tsinnarizin also reduces peripheral vascular cramps and improves blood circulation in obliteriruyuschem endarteriite, trombangiite, Reino disease, restless limp, akrotsianoze and other violations of peripheral blood,

     Accepted tsinnarizin inside after eating: the blood-brain violations typically 25 mg (one tablet) three times a day or 75 mg (1 capsule) 1 every day (There is evidence of the appointment of tsinnarizina in higher doses, up to 225 mg day.) ; when violations peripheral circulatory-50-75 mg (2 to 3 tablets) three times a day, or 2 to 3 capsules (75 mg each) daily. Apply product for a long time (courses from a few weeks to several months).

     In vestibular disorders are encouraged to 25 mg three times a day.

     For the prevention of sea and air sickness appoint one tablet (25 mg) for 30 min prior to departure; If necessary, take repeated at 6 to 8 h.

     The product is usually well tolerated by, sometimes perhaps a moderate fall, drought in the mouth, gastrointestinal disorders; In these cases, reduce the dose. When expressed arterial hypotension drug appointed in small doses (0,025 g 2 times a day). For some patients are older (or increase), extrapyramidal symptoms.

     Tsinnarizin increases of sedation and alcohol. Possibility sedative effects of drugs (especially in the early days of treatment) should be taken into account when he was appointed transport drivers and others whose work requires quick mental and physical reactions.

     Not recommended for pregnant drug appoint and breast feeding.

     Method of production: tablets of 0,025 g (25 mg) in the package of 50 cards; Capsules 75 mg (stugeron forte) in a package of 20 and 60 units, as well as drops in 20 ml vials containing 1 ml (25 drops), 75 mg tsinnarizina.

     Storage: List B. In sheltered from the world scene at room temperature.

Materials allowed to copy only with the active hyperlink to the handbook of medicines