TSIMETIDIN (Cimetidinum) *.

     Synonyms: Belomet, Gistak, Gistodil, Primamet, Simetidin, Tagamet, Tsimitiget, Tsinamet, Aciloc, Altramet, Belomet, Benomet, Besidin, Cimedal, Cimetar, Cimetiget, Cinamet, Gastromet, Histac, Histodil, Hystac, Neutronorm, Primamet, Simetidin, Surpamet, Tagamet, Tametin, Tamper, Ulcedon, Ulceratil, Ulcimet, Ulcomet, Zagastrol, Zontac and others.

     The main pharmacological effect tsimetidina is oppression sec SIP digestive juice associated with the closure H-2 receptors in the stomach wall. It oppresses spontaneous secretion and secretion, stimulated gistaminom, pentagastrinom, caffeine, as well as stretching the stomach, but little impact on karbaholinovuyu gipersekretsiyu because no antiholinergicheskoy tivnostyu Acad. It does not affect adrenergicheskie receptors, not having local anesthetic action.

     The product reduces the allocation of pepsin.

     Tsimetidin rapidly absorbed from the gastrointestinal tract. In the low lipofilnostyu he enters TSNS not have sedativ leg effect.

     Tsimetidin apply for the treatment of stomach ulcer disease and twelfth gastro cancer and other conditions that require lower giperatsid of digestive juice, including reflux ezofagite, Zola syndrome lingera-Ellison et al.

     Assign tsimetidin usually inside (after eating) adults in a daily dose of 0.8 to 1 g, which is divided into four reception: 3 x 0.2 and 0.2 g or 0.4 g of sleep. If necessary, increase the daily dose of 1 to 6 d. course of treatment usually 4 to 6 weeks (as necessary to 8 weeks). After an intensive course of treatment for supportive therapy for several months (to 0.4 g per night or morning and evening, 0.2 grams 0.2 grams).

     Stop receiving the drug, gradually reducing the dose. The sudden end to the admission could lead to a sharp increase in secretion and exacerbated disease.

     Tsimetidin can be used together with antatsidnymi drugs, but antatsidnoe funds should take an hour after receiving tsimetidina because while receiving Intake tsimetidina reduced.

     Tsimetidin give intravenous dose of 0.2 g (200 mg) at intervals of 4 to 6 hours The maximum daily dose of 2 grams in a drip dose of 0.1 g (100 mg) per hour for 2 hours; A repeat every 4 to 6 hours Maximum speed is limited to 150 mg per hour (or 2 mg / kg per hour). Intravenous introduction produce only hospital; With rapid intravenous a possible violation heart rhythms, and a strong decline in blood pressure.

     In applying tsimetidina can see various side effects: diarrhea, muscle pain, allergic reactions (skin plasma), headache, dizziness, depression. Are there changes in biochemical indicators (value transaminaz etc.). In a lengthy application of high doses of the drug can develop Gynecomastia, which is linked to the ability of a drug to stimulate prolactin secretion. There is also evidence that tsimetidin suppresses domestic product and factor vsasyvaemost vitamin B 12, and that he may have antiandrogennoe effect. There was also a change clearance vofaverdina indicating a deterioration vydelitelnoy liver function. The possibility of a return to repeal the drug and its side effects requires great caution in the appointment of a sick bolevnyu stomach ulcers and stomach cancer.

     In applying tsimetidina should monitor kidney and liver function, to the relevant biochemical studies to monitor the blood system.

     The product contraindications in pregnancy and breast feeding, patients with Disabilities liver and kidney; The product also contraindications children under the age of 14.

     Tsimetidin suppresses activity tsitohroma R-450 and other liver enzymes for metabolism and detoxification of many medicines, so it increases their toxicity and makes possible side effects (in particular, the peroralnyk antikoagulyantov). If the patient receives oral anticoagulated, in the case should be carefully chosen destination tsimetidina dose.

     Tsimetidin increases well as teofillina, difenina, b-adrenoblokatorov and other drugs (for the oppression detoxifying enzyme systems liver).

     Do not apply tsimetidin with diazepam (sibazonom) and hlozepidom because it prolongs the period of their half. Do not assign product while tsitostatikami and other drugs, causing neutropenia.

     Method of production: tablets of 0.2 g (200 mg); 10% solution in ampoule of 2 ml (0.2 g in the ampoule).

     Storage: List B.

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