TSILAZAPRIL (Cilazapril).

     9-Etilovy ether [1-karboksi-3- fenilpropil] amino] - 6 oktagidro-10- Ocso H piridazino [1,2 a] [1,2] - diazepinkarbonovoy acid.

     Synonyms: Inhibeys, Prilazid, Inhibace, Prilazid.

     The white crystalline powder. Poor soluble in water.

     According to the chemical structure differs in the absence of the molecule amino acid residues of a Captopril (L - proline), enalapril (alanil-L- L - proline), lizinoprila (lizil-L- L - proline), Ramipril (L-alanil) and sulfgidrilnyh groups.

     By pharmacological properties similar to other inhibitors APF.

     Quickly and completely absorbed in the digestive, T? at 11-12 h; given the kidneys.

     Apply with arterial hypertension and chronic heart failure.

     Assign inside.

     When arterial hypertension initial dose of 0,001 grams (1 mg) 1 hour per day (in conjunction with diuretikami, for the elderly and for violations of kidney function - 0.5 mg), supporting-0,0025-0,005 g (2, 5-5 mg) and the maximum is 0,005 grams per day.

     In congestive heart failure initial dose of 0.0005 g (0.5 mg) 1 every day, supporting-0,001-0,0025 g (1-2,5 mg), the maximum is 0,005 grams per day.

     Possible side effects basically the same as the Captopril. Sometimes there are growing cholecystitis, pancreatitis and gout; Arrhythmia, chest, kserostomiya.

     The product contraindications to angionevroticheskom swelling in history, violations of the liver and kidney, red systemic lupus, sclerodermia, sugar diabetes, gout, and giperkaliemii giperurikemii.

     Form release: pills to 0,001 g (1 mg) (N. 10, 30), 0.0025 g (2.5 mg) (7 N., 10, 28, 30) and 0,005 g (5 mg N.) (7, 28).

     Storage: List B.

Materials allowed to copy only with the active hyperlink to the handbook of medicines