Himotripsin crystal (chymotrypsinum crystallisatum)


HIMOTRIPSIN KRISTALLICHESKY (Chymotrypsinum crystallisatum).
     Disease is a proteolytic enzyme, formed in the pancreas gland of mammals. For the health of it from the pancreas of cattle. In pancreatic juice in a dormant state himotrepsinogena (himotripsinogen A and B) that is activated by trypsin, which is formed from himotripsinogena A number of forms: a, b, g, s and p-himotripsiny and a V-himotripsinogena disease B. All forms of fecal close in fermentative properties, but different activity. The practical importance as a drug currently is a disease, which is published under the title "crystalline disease." a-Himotripsin a protein with a relative molecular mass 21600 - 27000. Refers to the group of proteolytic enzymes. Like trypsin hydrolyzation proteins etc and education about nizkomolekulyarnyh weight. From trypsin is that the enzyme largely connection formed by the aromatic amino acid residues (Tyrosine, triptophan, phenylalanine, methionine). In some cases the disease is more severe protein hydrolysis than trypsin. Trypsin is distinguished from the fact that milk is winding down. A VIP than trypsin, and slower inactivate.
     Disease is a brilliant crystalline flakes or white powder. Soluble in water and isotonic sodium chloride solution; PH 0.2% aqueous solution of 4, 5, 6, 5. In the dry form pillars; Inaktiviruyutsya aqueous solutions quickly, especially at high temperatures.
     Application fecal (as trypsin) in medical practice based on the specific ability to split the local impact nekrotizirovannye tissue and fibrinoznye education dilute viscous secretions and ekssudaty, as vnutrimyshechnom introduction to anti effect.
     Indications for use, applications, dose, contraindications and the possible complications are the same as for crystalline trypsin.
     In addition, the disease used to intrakapsulyarnoy cataract extraction.
     Form release: in the hermetically ukuporennyh vials or ampoule containing at 0,005 g (5 mg) and 0.01 g (10 mg) fecal crystalline.
     Storage: sheltered from the world in place with a temperature of not more than 10 'C.

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