HIMOPSIN (Chymopsinum).

     Himopsin (or amorphous disease) from the pancreas butcher cattle. Contains a mixture - trypsin and chymotrypsin.

     Glowing skin powder or white or white with a yellowish sheen weak colors. Easy soluble in water and isotonic sodium chloride solution; PH 0.2% aqueous solution of 4, 5, 6, 5. Water solution must be colourless, transparent or weak Light, but not a draught. Solutions nestoyki, with a high temperature quickly inaktiviruyutsya, with a temperature of up to + 2 + 5 can be stored during the day.

     On biological properties similar to a himopsin - himotripsinom and trypsin, but less clear, and only for local use (festering wound on the surface and inhalation); Himopsin parenteral transmission can be applied.

     When treating festering wounds and dissolve straight 0,025 - 0,05 g (25-50 mg) himopsina 10 0.25% 50 ml solution Novocaine; Solution asbestos c terilnye napkins, which impose on the wound surface to 8 hours or more ( depending on the thickness of the layer structures necrotic). At the same time be appropriate antibiotics.

     In pre-degree burns III remove freely ottorgayuschiesya nekrotizirovannye fabric, and then have a thin layer himopsina (in the form of powders), covering a bandage, soaked in isotonic sodium chloride solution, or 0.25% solution of Novocaine boratnom buffer (pH 8, 6). Top place waterproof bandage. Bands change through the day. Before each of the following applications removed easily detachable parts necrosis. It may also be 0.5-1% solution himopsina. With the wounds covered by thick scab, scab chop to the drug entered into the tissue.

     Local himopsina application can be combined with the introduction of scab crystalline fecal (0.02 g in 20 ml of 0.25% solution of Novocaine).

     When treating corneal ulcers and keratitov apply legs with 0.2% solution or drops (0.25%) for 3 to 4 times a day for 1 - 2 - 3 days.

     For inhalations, and inflammatory diseases upper respiratory tract and lungs, dissolve 25-30 mg drug in 5 ml of sterile isotonic solution of sodium chloride and distilled water. The solution also can be entered through bronhoskop or endotrahealny probe. Inhalation repeat 1 to 2 times a day; The length of treatment depends on the nature and trends of disease. After inhalation should rinse the mouth and nose wash. In the hours after inhalation patient should carefully away alternative is for the sputum or should be to suck off. In himopsina solutions can add antibiotics and bronhorasshiryayuschie funds.

     In applying himopsina possible allergic reactions associated mainly with vacuum products proteolysis of necrotic tissue. Therefore, the application should identify the patient himopsina protivogistaminny product (Diphenhydramine or others). After inhalation himopsina sometimes ohriplost vote vanishing own.

     Can mark bystroprohodyaschaya subfebrilnaya temperature. In applying solutions himopsina for eye drops and sometimes there vannochek lymphatic tissue irritation and eye; In these cases, reduce the concentration of the solution or cease further use of the drug.

     Contraindications are the same as for trypsin and chymotrypsin.

     Form release: in the hermetically ukuporennyh vials or ampoule containing at 0,025; 0.05 and 0.1 g (25; 50 and 100 mg) himopsina.

     Storage: a dry, sheltered from the world scene with a temperature of not more than 20 'S.

Materials allowed to copy only with the active hyperlink to the handbook of medicines