HLORPROPAMID (Chlorpropamidum).

     N - (para-Hlorbenzolsulfonil) - N-propilmochevina.

     Synonyms: Bioglumin, Catanil, Chlorpropamide, Diabamide, Diabaryl, Diabet, Diabexan, Diabinese, Galiron, Mellinese, Prodiaben and others.

     The white crystalline powder without smell and taste. Almost nerastvorim in alcohol, benzene, acetone.

     For construction, pharmacological properties and the mechanism of close to butamidu; The chemically different from the past that the parameters of benzene nucleus contains Cl atom instead Group SNz instead butilnoy group (P 4 H 9) when N 'contains propilnuyu group (P 3 H 7).

     Relatively with butamidom hlorpropamid more active and has saharoponizhayuschee of smaller doses. It is antibacterial effect.

     Hlorpropamid rapidly absorbed from the gastrointestinal tract; Blood found in the first hours after admission; Peak concentrations in the blood is achieved through a 2 - 4 hours The product is available kidneys slowly, largely unchanged to. After receiving a hlorpropamida more resistant concentration in the blood. Duration of the drug after a single admission is 24-36 hours, so it can be taken once a day.

     Assign inside. In diabetes medium gravity expressed hyperglycaemia and glyukozuriey treatment starting with the reception 0.5 g 1 drug every day. Take the morning before eating (usually 7 am to 8 h). In light of diabetes begin with dose was 0.25 Without the effect of dose 0,25 g per day during the first week to increase the dose of 0.5 grams, and in some cases up to 0.75 g (during subsequent weeks) . If and when the effect will not be identified further appointment hlorpropamida inappropriate.

     Some patients need, in addition to the morning reception hlorpropamida appoint evening sulfonilmocheviny others.

     If normalization fast and address of the reception glyukozurii hlorpropamida gradually reduce its dose: 0,125 g for every two weeks, keeping the level of glucose in the blood and urine.

     Supporting dose, which still awards diabetes violations, usually 0,125 - 0.25 grams per day.

     When insulin hlorpropamidom appoint an estimated 0.25 g hlorpropamida instead of 20 ED insulin.

     Hlorpropamid also used to treat diabetes nesaharnogo. It is effective in some cases when refrakternosti drug pituitary (adiurekrinu, etc.) and their liver.

     Assign the inside, starting with 0,125 grams a day, gradually increasing doses of 0,125 g to 0,25 - 0,5 g (sometimes up to 0.75 grams) per day.

     The highest daily intake for adults inside the 1 year

     Time receiving the drug depends on portability. In order to avoid the development of curing it appropriate to once before or during breakfast; If bad portability (diarrhoeic phenomenon) product appointed immediately after the meal. In the evening reception is not recommended.

     When treating hlorpropamidom be followed the same precautions as in the admission of other drugs gipoglikemicheskih sulfonilmocheviny.

     Hlorpropamid generally well tolerated by. There are, however, side effects in the form of allergic reaction, radiation, thrombocytopenia, agranulotsitoza, diarrhoea. There may be a temporary phenomenon holestaticheskoy jaundice (mostly in the first few weeks of the start of treatment). The product must, therefore, be appointed with special care to those amenable to liver disease. A jaundice and liver function violations are absolute contraindications to the use hlorpropamida. Other contraindications are the same as for butamida.

     Please note that the elderly allocation hlorpropamida kidneys retarded. This requires a reduction of dosage.

     Form release: pills for 0.1 and 0.25 g.

     Storage: List B. The well ukuporennoy packaging.

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