TSEFAZOLIN (Cephazolin) *. [3-(5 - Methyl-1, 3, 4-tiadiazolil-2- tiometil) -7 - (1-tetrazolil- atsetamido) -3 tsefem-4] - carboxylic acid.

     Synonyms: Kefzol, Tsefamezin, Ase f, A ce n f, A tralcef, Sa ricef, facidal Se, Se f and mezin, Cefazolin, Celmetin, Gramaxin, Kefazol, Kefol, Kefzol, Kezolin, Reflin, Sefazol, Tefazolin, Totacef and others.

     Issued in the form of sodium salt-dried mass of white, soluble in water.

     Anticipated is a major tsefalosporinov first-generation broad-spectrum antibiotic, affecting bakteritsidno of gram and gram bacteria, including stafilokokki forming and forming penitsillinazu on Haemolytic streptococci, pnevmokokki, salmonella, shigella, certain Protea, microbes group By lebsiella, stick diphtheria, gonokokki and other microorganisms. It operates on rickettsiae, viruses, fungi and simple.

     Anticipated not absorbed in the employment inside. In vnutrimyshechnom a product quickly absorbed, the maximum concentration in the blood was after 1 h; The effective concentration after a single dose remains in the blood plasma during the 8 - 12 hours With intravenous imposing a higher concentration in the blood, but the drug available more quickly (half-time about 2 hours).

     Provided mainly (about 90%) unchanged to the kidneys.

     Anticipated permeates through the placenta barrier and found in the amniotic fluid. In lactating dairy detected in low concentrations.

     Apply anticipated when infection caused by susceptible to the gram and gram microorganisms: when respiratory tract infection, septitsemii, endocarditis, osteomielite, traumatic infection, infected burns, peritonitis, a urinary tract infection and others.

     Enter drug intramuscularly or intravenously (kapelno or struyno). For vnutrimyshechnogo razvodyat contents of the vial in 2 - 3 ml isotonic sodium chloride solution or sterile water for injection and enter deeply into the muscle. For intravenous jet introduction razvodyat single dose of the drug in 10 ml isotonic sodium chloride solution and impose slowly over 3 to 5 minutes. With intravenous drip introduction, the drug (0.5, 1, 0 g) razvodyat 100-250 ml isotonic sodium chloride solution, or 5% glucose solution, injection produced over 20 to 30 minutes.

     Daily dose for adults is anticipated from 1 to 4 grams (or more), depending on the severity of infection, a cause and its sensitivity to the antibiotic. If infection caused by micro gram, single dose for adults is usually 0.25 - 0.5 g; Enter three times a day (every 8 h). When infection airways medium gravity caused by pneumococcal, with a urinary diseases caused by microorganisms sensitive to the antibiotic, appoint 0,5-1, 0 g every 12 hours In diseases caused by gram sensitive to the antibiotic microorganisms appoint 0,5-1, 0 g anticipated every 6 to 8 hours Daily dose of sepsis, endocarditis and other serious diseases can be 6 g or more. Children appoint a rate of 20-50 mg / kg / day (3 - 4 admission); In heavy infections enter up to 100 mg / kg per day.

     Patients with kidney function violations vydelitelnoy anticipated appointed in small doses to avoid the cumulation.

     Like other sleep, anticipated can cause allergic reactions. In these cases, appoint ANTIALLERGICS drugs. Are there leukopenia, eosinophilia, neutropenia, nausea, vomiting. In vnutrimyshechnom a possible local pain of making.

     Contraindications to all tsefalosporinov (see).

     Form release: in vials of 0.25; 0.5; 1; 2 and 4 g.

     Storage: in a cool, sheltered from the world scene.

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