TSEFOTAKSIM (Cefotaxim) *.

     Tsefalosporinovy antibiotic third generation.

     Issued in the form of sodium salt.

     Synonyms: Klaforan, Cefotax, Chemcef, Claforan, Cloforan, Klaforan, Primafen, Ralopar and others.

     According to the chemical nature of competitive tsefalosporinam close to the first and second generations, but especially structures provide high activity against gram bacteria develop resistance to their actions produced b-laktamaz. The product has a wide range of actions; A bakteritsidno and gram for gram of microorganisms that are resistant to other tsefalosporinam, penicillins and other means of resistance.

     Apply competitive intramuscularly and intravenously; Admission inside it is not absorbed. In vnutrimyshechnom a drug absorbed quickly. Peak concentrations in the blood plasma is 30 minutes after injection. Bactericidal concentration in the blood stored more than 12 hours The product is well into the tissue and body fluids; Found in effective concentrations in the blood, peritoneum, sinovialnoy fluid. Report the significant quantities of urine from unchanged to (about 30%) and in the form of active metabolites (20%). Partly derived from export.

     Apply competitive with infections caused by susceptible pathogens to it: respiratory tract infections and urinary track, kidney, ear infection, sore throat, nose, septitsemii, endocarditis, meningitis; Infection bone and soft tissue, abdominal and gynecological infectious diseases, gonorrhea and others.

     For intramuscular injections dissolve 0.5 g tsefotaksima in 2 ml (1 g, respectively, and 2 g of 3 and 5 ml), sterile water for injection. Enter deep into the rump muscles. To introduce veins dissolve 0.5 g of 2 ml (1 g or 4 ml and 2 g in 10 ml), sterile water for injection. Enter slowly over 3 to 5 minutes. For drip introduction (for 50-60 min) dissolve 2 g of the drug in 100 ml isotonic sodium chloride solution, or 5% glucose solution.

     Tsefotaksima normal dose for adults and children over 12 years, 1 g every 12 hours In severe cases, up to a dose of 2 g every 12 hours or increase the number of introductions to 3 to 4 times a day, bringing the total daily dose to the maximum- 12 g.

     Normal intake for infants and young children 50-100 mg / kg / day, divided into separate receptions with intervals of 12 to 6 hours For premature children, the daily dose should not exceed 50 mg / kg. Violations dose reduced kidney function. In early anurii (emphasis kreatinina 5 mL / min) usually reduces the dose in half.

     Using tsefotaksima possible allergic reactions, digestive disorders, increased eozinofilov, leukopenia, neutropenia, improved liver tests, the level of alkaline fosfotazy and nitrogen content in urine. May develop phenomenon irritation at the injection site, the temperature rise.

     Contraindications to all tselofalosporinov.

     Form release: in vials of 0.5; 1 and 2 years

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