TSEFEPIM (Cefepim).

     1-[[7-[[(2) (Amino-4- tiazolil metoksiimino) acetyl] - amino] - 2 karboksi-8- okso-5- tia-1- azabitsiklo [4.2.0] okt- 2-en-forces] methyl] -1 - metilpirrolidiniya hydrochloride.

     Synonym: Maksipim, Maxipime.

     Powder white or pale yellow. Easy soluble in water.

     Tsefalosporinovy fourth generation antibiotic.

     He has a broad range of actions. Active against gram and gram bacteria (including those resistant to the third generation and tsefalosporinam aminoglikozidam), as well as anaerobov. Vysokoustoychiv to most? - Laktamaz (especially chromosomal).

      After vnutrimyshechnogo of C max is 1.5 h, T? h-2 (with severe kidney failure to 13-19 h); being biotransformation, appears mainly kidneys.

     Implemented with heavy (including sinegnoynyh) lower respiratory tract infections, urinary track, abdomen, skin, soft tissues, bones and joints, with septicaemia, endocarditis and meningitis.

     Assign intravenously (within 3-5 minutes) or intramuscularly to adults 0,5-1- g (with heavy infection, 2 g), 2 times a day (in violation of the functions of the kidney-0,25-1 through 12-24 g h ); children - at the rate of 50 mg / kg every 8-12 h. The course of treatment-7-10 days or more.

     Possible side effects: diarrhoeic phenomenon, headache, dizziness, paresthesia, convulsions, tachycardia, peripheral swelling, anaemia, increased protrombinovogo time, allergic reactions, etc.

     Contraindications: age under 13 years.

     Form release: dried powder for injection solutions in vials of 0.5; 1 and 2 years

     Storage: List B.

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