TSEFALORIDIN (Cefaloridinum) *.

     Polusintetichesky antibiotic obtained on the basis of 7-aminotsefalosporanovoy acid (7-ACC).

     Synonyms: Tseporin, Aliporina, Ampligran, Cefalisan, Cefalobiotic, Ceflorin, Cepaloridin, Cepalorin, Cephalomycine, Cephaloridine, Ceporan, Ceporin, Cinorin, Endosporol, Gencefal, Glaxoridin, Intrasporin, Keflodin, Keflordin, Latorex, Lauridin, Loridine, Prinderin, Sasperin, Sefacin, Sintoridyn, Total-minicina and others.

     The white crystalline powder, well-soluble in water. Aqueous solutions age to light.

     The product provides antibacterial effect on gram and gram kokkovye microorganisms (stafilokokki, pnevmokokki, streptococci, gonokokki, meningokokki), anthrax sticks. Force stafilokokki resistant to penicillins. Effective on spirohet and leptospir. It operates on Mycobacterium tuberculosis, rickettsiae, viruses, protozoa.

     Like penicillins tsefaloridin has microbicides effect.

     The mechanism of pain associated with inhibition of cell membranes of bacteria.

     When you receive inside tsefaloridin poorly absorbed, so apply parenteral transmission. In vnutrimyshechnom and intravenous therapy is a rapidly concentration in the blood and tissues. In spinal fluid penetrates slowly. There were mostly unchanged to the kidneys; Violation vydelitelnoy kidney function, slowing down from the body.

     Apply with acute and chronic infection of the respiratory system, urinary track, genital organs, soft tissue infections, peritonitis, postoperative infection, sepsis, endocarditis, syphilis and other infections caused by susceptible to microbial products. There was good preparation for gonorrhea.

     Good results have to treat tsefaloridinom resistant to the antibiotic stafilokokkovyh infections, including pneumonia severe sepsis, septitsemii, septic endocarditis.

     The product can be used in allergy to penicillins.

     Enter predominantly intramuscularly. Intravenous (mikrostruyno or kapelno) to impose heavy during infection and the need for rapid creation of high antibiotic concentrations in the blood. You can also enter cavity (chest, abdomen), endolyumbalno.

     In moderately serious infections caused by gram bacteria enter the adult rate of 20 - 30 mg / kg / day (2 - 3 admission).

     When infections caused by gram bacteria designate adults and children 40-60 mg / kg / day (2 - 3 admission), with a very heavy infection (endocarditis, sepsis) and chronic bronchitis eight - to 60100 mg / kg / day (2 - 4 admission). Newly appointed at the rate of 15 30 mg / kg / day (2 admission), children aged 20 -30 mg / kg.

     The highest daily intake for adults 6 g.

     In empieme aswellaspleuralplaques impose additional chest cavity of 0.25 g drug.

     When meningitis appoint intramuscularly or intravenously, children under 60 mg / kg per day for adults, 1 g every 6 hours In the first 5 to 7 days to introduce additional products every day or every other day endolyumbalno. The highest single dose for adults is 50 mg endolyumbalno (0.05 g) of 2-10 ml isotonic sodium chloride solution, for children up to 15 years - 1 mg / kg.

     Before the introduction endolyumbalnym should carefully check solution; Painted solutions can be applied.

     When a urinary tract infection tsefaloridin in its allocation of significant quantities of kidneys can be used in lower doses than other infection: appoint usually at the rate of 15 - 30 mg / kg / day (0.5 g for adults 2 to 3 times a day 1 or 2 grams per day). With inadequate preparation appoint kidney function with caution in small doses.

     Solutions tsefaloridina produce directly to the introduction, using sterile water for injection. For intramuscular injection, 2 g tsefaloridina dissolve in 4 ml of water, 1 g in 2.5 ml; 0.5 g in 2 mL and 0.25 grams in 1 ml of water. For intravenous injection 0,5-1, 0 g drug dissolved in 2.0-2.5 mL of sterile water, razvodyat additional 10-20 ml isotonic solution of sodium chloride or glucose (5%).

     Intravenous injections are within 3 to 5 minutes or enter solution droplets way (within 6 hours).

     Solutions typically used immediately after preparation. When standing solution possible fallout of crystals. A solution, if it does not enter immediately, should stir, despite the fact that it appears transparent.

     At room temperature (below + 25 'C) solution remains active within 24 hours, and the storage in the refrigerator for a period of 4 days.

     Using tsefaloridina in high doses (6 g / day for adults) may appear in the urine gialinovyh cylinders and other cell components; Rarely can disrupt Excretory function of the kidney. Possible allergic reactions. Sometimes there anafilakticheskaya reaction. In some cases, developing neutropenia. In endolyumbalnom a phenomenon may occur irritation coats the brain and transitory movement. In vnutrimyshechnom a possible local irritation and erythema (not requiring the lifting of the drug). After intravenous pain can be tricky during the vein and erythema; To avoid trombophlebitis recommended solution drug every time out. If there is a generalized erythema injections cease.

     The product contraindications to tsefalosporinovym heightened sensitivity to antibiotics. It should not be appointed in the first months of pregnancy.

     It should be noted that the urine of patients poluchayushih tsefaloridin gives a false positive for glucose (dying in a brownish black), to determine if the use medsoderzhaschih reagents.

     Form release: in vials of 0.25; 0,5 and 1 year

     Storage: List B. In sheltered from the world scene with a temperature higher than  +10 C.

Materials allowed to copy only with the active hyperlink to the handbook of medicines