KARVEDILOL (Carvedilol).

     (±) -1 - (Karbazol-4- iloksi) -3-[[2 - (ortho metoksifenoksi) ethyl] amino] -2-propanol.

     Synonyms : Dilatrend, Kredeks, Credex, Dilatrend.

     The structure can be considered as a modified (karbazolsoderzhaschy) analogue? - Adrenoblokatorov.

     Perfect indiscriminate effects on blocking? - Adrenoretseptory campaign? 1-adrenoblokiruyuschey activity; Also has antioxidant properties.

     According to reports, karvedilol favorable effect on the level of lipid and lipoprotein blood plasma.

     Applied with arterial hypertension (the most effective for moderate forms of hypertension) and strokes.

     The drug also used to treat patients with chronic congestive heart failure (coupled with a "standard" methods of therapy, digoxin, diuretikami, ACE inhibitors).

     Assign inside.

     With arterial hypertension start with 0.0125 g (12.5 mg) once a day; After 2 days increases the dose to 0,025 grams (one). If necessary, the dose gradually increased to 0.05 g / day or use in combination with ACE inhibitors and diuretikami.

     When strokes appoint 0,0125-0,025 g (12,5-25 mg) two times a day.

     In heart failure start with a small dose-0.003125 grams (3,125 mg), 2 times a day; After 2 weeks of increased twice (6.25 mg), and then govern according to the impact, endurance and weight patients (maximum daily intake 0,05-0,1 g).

     As published in the foreign literature indicates that in patients with congestive heart failure who received ACE inhibitors, diuretics or cardiac glycosides, adding to karvedilola lead to a decrease in overall mortality, the rate of sudden death, death from heart failure and the frequency of hospitalizations.

     The drug is usually well. However, in its application may Orthostatic Hypotension, urination disorders, impotence, depression, thrombocytopenia, radiation, increasing the activity of liver enzymes and other side effects common to? - Adrenoblokatorov (see Anaprilin).

     Indications are the same as the other? - Adrenoblokatorov (see Anaprilin).

     Heart diseases and diltiazem increase dampening effect on karvedilola atrioventrikulyarnuyu conductivity.

     Product : pills to 0.00625; 0.0125 and 0.025 g (6.25; 12.5, and 25 mg) (N. 10, 30).

     Storage : List B.

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