KARMUSTIN (Carmustine).

     1,3-bis - (2-Hlormetil) -1 - nitrozomochevina.

     Synonym : BiKNU, BiCNU.

     Liofilno mass dried flakes or pale yellow. A well soluble in alcohol, bad-in the water. There is a low melting point (30 ° C).

     Like lomustinu and nimustinu contains molecules hloretilny substituent.

     By activity and toxicity similar to lomustinom.

     The drug and its metabolites quickly penetrate the blood-brain barrier; In high concentrations found in the spinal fluid.

     Applied in the brain and digestive tract tumors, multiple myeloma, chlamydia, malignant melanoma, Ewing sarcoma.

     Enter intravenously at 200 mg / m 2 once (for the first time hospitals patients) or 75-100 mg / m 2 consecutive days every six weeks. Diluted dissolve in 3 ml attached solvent and then 27 mL of sterile water for injection.

     When used in combination with other therapy dose of drugs to reduce 25-50%.

     Product : dried powder for injection solutions in bottles of 0.1 g complete with a solvent (3 ml).

Materials allowed to copy only with the active hyperlink to the handbook of medicines