KARMINOMITSIN (Carminomycinum).

     Antibiotics, produtsiruemy radiant fungus Actinomadura carminata, antratsiklinovyh belongs to the group of antibiotics.

     Make as hydrochloride-crystalline powder or porous red. Mg in the water.

     Applied therapy with other drugs and radiation therapy in the form of disseminated breast cancer, lung okroshka bone and soft tissues, Chlamydia and other malignant tumors.

     Vysokoeffektiven in malignant tumors in children (simpatoblastoma, Wilm's tumor, rabdomiosarkoma etc.). Relatively with rubomitsinom, doxorubicin have less cardiovascular, and gepato- nefrotoksichnostyu.

     Enter karminomitsin intravenously in two versions therapeutic regime.

     When <<extended>> regime appointed to 10 - 15 mg (5-7, 5 mg / m 2 = 0.15 - 0.2 mg / kg), 2 times a week; Exchange dose for adults 60-75 mg ( 35-45 mg / m 2), interval training four weeks. For patients receiving intensive chemotherapy before radiation therapy or Course dose should not exceed 50 mg (single 10-mg). Children entering the rate of 0.15 mg / kg.

     When <<short>> drug treatment imposed on 5 - 10 mg (3 to 5 mg / m 2 = 0.1 - 0.15 mg / kg) daily for 5 days; In the course of 20-25 mg / m 2. interval training 3 to 4 weeks. Assign also karminomitsin short courses to 5 mg intravenously daily for 5 days followed by a suspension of two weeks. After 2 weeks to the regular course of 5 mg daily for 3 to 5 days.

     When radiation (less than 2 x 10 9 / L) and thrombocytopenia (less than 100 x 10 9 / L) to the next lower dose rate of 25-50%.

     Solutions karminomitsina prepared immediately before use. The contents of a bottle (0,005 g = 5 mg) dissolved in 10 ml isotonic sodium chloride solution. Enter intravenous (when getting under the skin tissue necrosis possible).

     In applying the drug may be nausea, vomiting, leyko- and thrombocytopenia, kardiotoksicheskie phenomenon : pain in the heart, tachycardia, ECG changes (see Doksorubitsina hydrochloride).

     Changes in the blood picture can be observed directly in 1 and 2 weeks after injection of preparation. Monitoring of blood platelets and should therefore be recognized as during treatment, and within the next two weeks (two times a week). In cardiovascular violations should be reduced single dose (30-50%), increase the interval between injections to appoint a medicinal therapies.

     The drug is contraindicated in patients generally serious condition, related heart disease, violations of liver and kidney, with content in the blood of less than 4 x 10 9 / L leukocyte and 100 x 10 9 / L platelets in pregnancy.

     Product : in vials of 0,005 grams (5 mg).

     Storage : List A. dry, the dark spot.

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