KARBUTAMID (Carbutamide).

     N (para-Aminobenzolsulfonil) -N- butilmochevina.

     SINONIMY : Bukarban, Oranil, Bucarban, Diabecid, Diaboral, Glucidoral, amid Hypogly with, Invenol, Midosal, Nadisan, Orabetic, Oranil, Sulfadiabet and others.

     The white crystalline powder slightly bitter taste. Almost nerastvorim in water, soluble in alcohol.

     Rapidly absorbed in the digestive tract, with max of 1 hour, T1 / 2 to 36 h; Biotransformaschsh is in the liver, kidneys displayed.

     Saharoponizhayuschee of karbutamida most expressed in the first 5-7 h after administration and lasts up to 12 hours (after a single admission).

     As with other drugs in this group, used mainly in type II diabetes.

     Assign the interior (for 1 hour before meals). Earlier take care of 2 g / day, 1 g (2 pills for 0.5 g) in the morning (usually 7-8 hours) and 1 g-night (at 17-18 h). Increasing doses of more than 2 g to mounting effect, as a rule, does not.

     After two weeks after the removal glyukozurii and normalize blood glucose dose can be reduced to 1 g and 0.5 g morning in the afternoon, and while maintaining good performance through the same period, to 0.5 and 0.5 g morning g evening. Admission preparation in this dose continue for a period of not less than one month and later with a good performance to reduce the daily dose of 0.5 or 0.25 grams or less (depending on the results of studies).

     In light where treatment can begin with two doses of 0.5 grams per day, with the consequent increase in ill effect.

     While transferring patients receiving insulin (a violation Carbohydrate exchange offset in insulin doses less than 40 ED / day), the latter shall karbutamid dose of 1 g, 2 times a day and reduce by half the dose of insulin. Further clarification dose of insulin, the reduction or elimination of the drug produced by urine tests (glucose and acetone) and blood (glucose). If compensation for the violations of diabetes requires less than 10 ED insulin a day, it can cancel immediately and appoint karbutamid 1 g 2 times a day.

     In cases where in the first weeks of treatment karbutamidom hyperglycemia and glyukozuriya not eliminated, usually moving to a more active drug or drug combination sulfanilamidny with biguanidinovym if the same compensation violations metabolism can be reached using insulin.

     Treatment karbutamidom, like other similar drugs, is being held under medical observation. Patients must abide by the diet. Neobhododimo systematically monitor blood glucose (morning PCP), and daily urine; Before and during the initial period of treatment, these studies are carried out daily. In the process of treatment should be regularly common blood test.

     Possible side effects : hypoglycemia, diarrhoeal phenomenon (due to the suppression of intestinal microflora), disruption of the liver and thyroid, radiation, atranulotsitoz, haemolytic anaemia, allergic reactions. If the side effects are not medicines overturned.

     When hypoglycemia reduces dose; If necessary designate glucose and hold such events as when insulin overdose.

     The drug is contraindicated in prekomatoznom and coma, ketoacidosis, acute infectious diseases, milder forms of diabetes (offset by a diet), violations of the liver and kidney, radiation, granulotsitopenii, rapid intervention, allergic reactions to drugs sulfanilamidnye during childhood and adolescence, pregnancy , pp.

     FORM OUTPUT : pills to 0.5 g (N. 50).

     STORAGE : List B.

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