KARBAMAZEPIN (Carbamazepinum). 5-Karbamoil-5 H-Dibenzo (6 f) azepin.

     Synonyms : Stazepin, Tegretol, Finlepsin, Amizepin, Carbagretil, Carbamazepin, Carbazep, Finlepsin, Mazetol, Neurotol, Simonil, Stazepin, Tegretal, Tegretol, Temporal, Zeptol and others.

     The white crystalline substance. It is soluble in water.

     On chemical structure is derived iminostilbena containing the situation 6 karbamoilnuyu group that mainly determines the availability of drugs protivosudorozhnoy activity.

     Structurally, carbamazepine close to dibenzoazepina tricyclic antidepressants group (see Imipramin).

     Carbamazepine has expressed protivosudorozhnoe (protivoepilepticheskoe) and a moderate degree of antidepressant (timolepticheskoe) and normotimicheskoe effect.

     In the framework of carbamazepine play a role his GAMKergicheskie properties (see Atsediprol), as well as interaction with the central adenozinovymi receptors.

     When ingestion vsysyvaetsya with different speeds at different 6 hemophilia. Peak concentrations in plasma observed by 4-8 h, and kept to 24 hours Period polususchestvovaniya in plasma ranges from 10 to 20 hours

     Applied carbamazepine in psychomotor epilepsy, fits large, mixed forms (mostly in combination with large fits psychomotor poverty), the local form (post and postentsefaliticheskogo origin). In small fits inadequate.

     Assign inside (while eating) adults, from 0.1 grams (1 / 2 tablets) 2-3 times a day, gradually increasing the dose to 0.4, 1, 2 grams (4-6 tablets) a day.

     Average daily intake for children is 20 mg per 1 kg of body weight, an average of up to the age of 1 year from 0.1 to 0.2 grams per day; From 1 to 5 years 0,2 - 0,4 g; from 5 to 10 g 0.4 - 0.6 g; 10 to 15 years - 0.6 1 g per day.

     You can assign carbamazepine in combination with other drugs protivoepilepticheskimi.

     Just as with the application of other protivoepilepticheskih drugs for treatment karbamazelinom transition should be gradual, reducing dose of the drug. Termination treatment carbamazepine also be gradual.

     There is evidence of the effectiveness of the drug in some cases in patients with various giperkinezami. Initial dose of 0.1 g gradually (through 4 - 5 days) increased to 0.4, 1, 2 g per day. After 1 - 4 weeks. to reduce the dose of 0.1 - 0.2 g / day, and then in the same doses appoint or every day in a 1 - 2 weeks.

     Carbamazepine has also applied for the treatment of affective disorders. According to reports, medication is effective in manic depressive state, with its more than expressed in Manic syndrome than in the depression. However, in depressions, he has a preventive effect. In some cases, carbamazepine more effective than drugs lithium and less toxic. In combination with lithium may increase the neurotoxic side effects.

     Carbamazepine has analgeziruyuschee up at troynichnogo nerve disease. The effect of varying degrees have some other drugs convulsants (ethosuximide, Trimethadione, etc.).

     It is estimated that at the core of this particular action convulsants drugs is some common pathogenetic mechanisms trigeminalnoy disease and epilepsy.

     Assign carbamazepine in the chamber troynichnogo nerve from 0.1 g, 2 times a day, then increase the dose of 0.1 grams per day if necessary to 0.6 - 0.8 g (3 - 4 admission). The effect is usually 1-3 days after the start of treatment. After disappearing more gradually reduce the dose (up to 0.2-0.1 grams per day). Assign drug long; In early lifting of pain drugs may resume. Carbamazepine is currently regarded as one of the most effective means to this pathology.

     The drug is usually well. In some cases, possible loss of appetite, nausea, rarely, vomiting, headache, drowsiness, ataxy breach of accommodation. Reducing or disappearance of side effects occurred in the suspension or reduction of reception drug doses. There is also a reported allergic reaction, radiation, trombotsitopepii, agranulotsitoze, hepatitis, skin reactions eksfoliativnom dermatitis. When these reactions reception drug stop.

     It should be borne in mind the possibility of mental disorders in patients with epilepsy, patients carbamazepine (tegretolom).

     Carbamazepine in the treatment process to systematically monitor blood picture. Do not assign product in the first three months of pregnancy. Carbamazepine should not be appointed concurrently with irreversible inhibitors monoaminoksidazy (nialamidom et al furazolidonom) for the opportunity to strengthen the side effects. Phenobarbital and Primidone weaken protivoepilepticheskuyu activity carbamazepine.

     The drug is contraindicated in violation of cardiac conductance, liver damage

     Product : 0.2 grams of pills in a package of 30 or 100 pieces.

     Storage : List B.

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