Kapetsitabin (capecitabine)


KAPETSITABIN (Capecitabine).
     Pentil 1-(5-deoksi-? -D- Ribofuranozil) -5 - fluorine-1, 2-digidro-2- okso-4- pirimidinkarbamat.
     Synonym : Kseloda, Xeloda.
     Like ftorafuru is prolekarstvom ftoruratsila (turning it in Tumor Cells).
     Antimetabolit pirimidina (ingibiruet timidilatsintetazu).
     Quickly and completely absorbed in the digestive tract, C max at 1.5 h, T? - 3-4 h is biotransformation in the liver and Tumor Cells, presented mostly kidneys.
     Applied with large bowel cancer, breast, ovary.
     Assign inside (after 30 minutes after eating) of 2.5 g / m 2 per day (2 admission) within 2 weeks, a second course after 1 week.
     Possible side effects : neutropenia, thrombocytopenia, anemia, dry mouth, anorexia, diarrhoeal phenomenon parestezii, swelling, watering, hyperpigmentation.
     Contraindications : pregnancy, breast-feeding.
     Product : pills to 0.15 g (N. 60) and 0.5 g (N. 120).

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