BUTIROKSAN (Butiroxanum).

  6-[4 - (3-Fenilpirrolidinil-1) - butiril] benzo-1, 4-dioxane hydrochloride.

     The white crystalline powder. Slow and difficult to dissolve in water and alcohol.

     The structure is close to pirroksanu; There is only one more methylene groups (-CH 2) in the side chain.

     For action has been close to pirroksanu. Is-adrenoblokatorom providing peripheral and central adrenoliticheskoe effect. Partially blocking central n holinoretseptory.

     Butiroksan applied for edema, prevention and treatment gipotalamicheskih vegetososudistyh distony simpatiko- tonic nature involving vegetososudistymi crises with increased blood pressure. Unlike pirroksana particularly effective in stem vegetososudistyh dystonia vagoinsulyarnogo type, leaking without raising blood pressure, and even with its lower, in mixed form of the disease. In addition, the drug is recommended for the treatment of hypertension, especially in their propensity to PNDS crises.

     Butiroksan recommended for the treatment of opioid syndrome in alcoholism and drug addiction. It oppresses attraction to drink alcohol or narcotic drug.

     Applied butiroksan inside, subcutaneously or intramuscularly. Inside take on the 0.01 g 1 to 4 times a day; Parenteral impose on 1 - 2 ml of 1% solution of 1 to 4 times a day.

     Length receiving drug and determine the dose to each patient individually.

     For the treatment of alcohol withdrawal symptoms and cravings syndrome with polydrug impose butiroksan for parenteral 0.02 g (2 ml of 1% solution) every 4 h during the two day. Then a supportive therapy, injections or tablets inside of 1 to 2 times a day for 3 to 4 weeks.

     For cerebral edema PNDS crises simpatiko- adrenalovoy Nature gives the best effect intramuscular a 1 - 2 ml of 1% solution of 1 to 2 times a day. In mezhpristupnom period imposed butiroksan subcutaneously or intramuscularly for 0,005 - 0,002 grams a day (10 to 15 injections) or designate the interior of 0.01 g for 2 weeks.

     In hypertensive butiroksan designate the interior of 0.01 g 1 to 2 times a day for parenteral or 0,5-1 - 2 ml of 1% solution for 10 of 15 days.

     Higher doses for adults : single-inside 0.04 g, 0.03 g injections; Daily-inside 0.18 g, 0.15 injections in the city

     In applying butiroksana could experience a drastic reduction in blood pressure, aetiology. In these cases should be abolished and a symptomatic drug therapy (mezaton, ephedrine, a means of koronarospazma), with a subsequent decrease dose of the drug.

     In the case of the treatment dose of the drug reduced.

     Butiroksan not recommended expressed in heart failure and low blood pressure (hypotension clear), as well as edema cramping syndrome III stage alcoholism.

     Method of production : tablets of 0.01 g; 1% solution in ampoules (colourless transparent liquid) and 1 ml (Solutio In utiroxini 1% p ro injectionibus) in a package of 10 vials.

     Hranenne : List B. In the dark spot.

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