BUTAMID (Butamidum).

     N - (para-Metilbenzolsulfonil) - N-n-butilmochevina :

     Synonyms : Aglycid, Arcosal, Artosin, Beglucin, D-860, R Diabecid, Diabetamid, Diabetol, Dirastan, Dolipol, Mobenol, Neoinsoral, Orabet, Oresan, Orinase, Rastinon, Tolbusal, Tolbutamide, Tolbutamidum, Tolumid, Toluvan and others.

     The white crystalline powder slightly bitter taste. Almost nerastvorim in water, soluble in alcohol.

     He is one of the main representatives of oral sulfonylureas gipoglikemiziruyuschih derivatives. Saharoponizhayuschee most of the drug expressed in the first 5 to 7 h after administration and lasts up to 12 hours (after a single admission).

     As with other drugs in this group, used mainly in type II diabetes.

     Assign inside. Early treatment given to 2 g / day, 1 g (2 pills for 0.5 g) the patient takes the morning, one hour before meals (usually 7 to 8 am) and 1 g of 5 - 6-hour evening. Increasing doses of more than 2 g acceleration of the effect usually does not.

     The beneficial effects of the drug is usually during the first 2 to 3 weeks (in some patients during the 1 st week). After removing glyukozurii and normalization of blood glucose after 2 weeks dose can be reduced to 1 g and 0.5 g morning in the afternoon, and while maintaining good performance through the same period, to 0.5 and 0.5 g morning g afternoon. During at least one month continue receiving the drug in the dosage, and later with a good performance to reduce the daily dose of 0.5 or 0.25 grams or less (depending on the results of studies).

     In light cases treatment can begin with two doses of 0.5 grams per day, with the consequent increase in ill effect.

     Translated into treatment butamidom patients receiving insulin (compensation violations Carbohydrate share achieved in insulin doses less than 40 ED / day), butamid designate dose of 1 g, 2 times a day and reduce by half the dose of insulin. Further clarification dose of insulin, the reduction or elimination of the drug produced by urine tests (glucose and acetone) and blood (glucose). If compensation for the violations of diabetes requires less than 10 ED insulin a day, it can be cancelled immediately and appoint butamid 1 g 2 times a day. If the first weeks of treatment butamidom ginerglikemiya and glyukazurin not eliminated, should go to the treatment of active drug or combination of drugs with sulfanilamidnogo biguanidinovym and if compensation violations metabolism not come, we must turn to be treated with insulin.

     Higher doses butamida for adults inside : single 1, 5 grams daily 4 years

     Treatment butamidom produced under the close supervision of a doctor; Patients must abide by the diet; Systematic Study of blood glucose (morning PCP), and daily urine; Before treatment, and the first time these studies produce daily. In the treatment process must systematically common blood test.

     Butamid malotoksichen, but in some cases can be side effects : headache, diarrhoeal phenomenon, allergic reaction (itching, dermatitis), radiation, thrombocytopenia, a violation of liver function. If the side effects are not medicines overturned.

     When hypoglycemia reduces dose butamida; If necessary designate glucose and hold such events as when insulin overdose.

     If during treatment butamidom a resistance to it, should be replaced butamid saharoponizhayuschim other oral drugs or insulin.

     Butamid contraindicated in prekomatoznom and coma, ketoacidosis in childhood and adolescence, pregnancy and lactation, acute infectious diseases, milder forms of diabetes (offset by a diet), violations of liver and kidney functions, radiation, granulotsitopenii, rapid intervention, allergies to sulfanilamidnyh use drugs.

     Product : tablets for 0.25 and 0.5 g.

     Storage : List B. The well ukuporennoy package in a dry place.

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