BUTADION (Butadionum). 1, 2-Difenil-4- butilpirazolidindion- 3, 5.
Synonyms : Alindor, Antadol, Arthril, Arihrizon, Artrizin, Artropan, Azobutil, Butalan, Butalgin, Butalidon, Butapirazol, Butartril, Butazolidin, Butazone, Butofar, Butosal, Butylpyrin, Colbutan, Curozoladin, Delbutan, Deltabutanyl, Dibutone, Diphenylbutazon, Elmedal, Eributazone, Fenibutasan, Fenilbutazona, Fenylbutazon, Mephabutazon, Merizone, Nadozone, Novophenyl, Panazone, Phebutan, Phenbutazol, Phenopyrine, Phenylbutazon, Phenylbutazonum, Rheumaphen, Rubatone, Sedazole, Todalgil, Zolaphen and others.
White or white to slightly yellowish sheen powder. Almost nerastvorim in water, soluble in alcohol difficult; Dissolve soda in the soda solution. On chemical structure Phenylbutazone is derived antipirina close amidopirinu. Has analgesic, antipyretic and anti-inflammatory; But antiinflammatory activity exceeds Phenazone and Amidopyrine and therefore considered as one of the main representatives of non-steroid anti-drugs.
Phenylbutazone is relatively strong biosynthesis inhibitor prostaglandines, bigger in this regard atsetilsalitsilovuyu acid.
The drug is rapidly absorbed and relatively long in the blood.
Applied for the treatment of acute rheumatic fever, acute, subacute and chronic Rheumatoid poliartritov, infectious nonspecific poliartritov, acute disease, gout, arthritis psoriaticheskih, fingers erythema, low trochaic.
Phenylbutazone can be used in combination with hormonal therapy (Corticosteroids), hingaminom (see).
When arthritis various etiology Phenylbutazone quickly reduces pain and inflammation reaction; He also pain gout attacks, reduces the content of uric acid in the blood. There are performance butadiona with throm veins of lower limbs and gemorroidalnyh vein : drug use was causing pain, swelling, hyperemia and significant improvement in the general (with these diseases can be applied ointment containing Phenylbutazone). There are also indications of a positive effect butadiona with red lupus. A good effect (decrease exudation and pain) marked with iridotsiklitah.
Assign Phenylbutazone inside during or after eating. Under the dose for adults 0.1 - 0.15 g; During the day, drug taking 2 - 3 times; A daily dose of 0,45 - 0,6 g. After the improvement dose can be gradually reduced to 0.3 - 0.2 city Children (aged 6 months) Assign 3 to 4 times a day to 0.01 - 0.1 grams, depending on age. The length of treatment depends on the case and may reach 2 to 5 weeks or more.
Perhaps a combination of butadiona with other anti-anxiety drugs.
Higher doses butadiona for adults inside : single 0.2 g daily 0.6 g.
When treating butadionom can often arise about side effects : delay fluid in the body, nausea, vomiting, pains in the stomach (medication has ultserogennoe action), increased stool, skin rashes, itching, urticaria, radiation (agranulotsitoz) and anaemia, haemorrhage (hematuria ), neuritis and others.
For those with a heightened sensitivity to butadionu appropriate after 2 to 3 days of treatment conventional doses gradually reduce the dose to 0.25 - 0.3 grams per day. Treatment must be carried out under the close supervision of a physician.
To reduce diarrhoeal phenomena can be appointed non-alkali Antacids funds. Reduced blood cells or other blood changes, as well as allergic reactions are testimony to the lifting of the preparation. In the treatment process to be systematically studied blood.
Phenylbutazone is not suitable for stomach ulcers and gastrointestinal cancers (stomach bleeding possible), haematopoietic diseases, radiation, in violation of the functions of the liver and kidneys, circulatory failure B II and III level, a heart rhythm irregularities. Caution should be exercised in gastritis and gastroenteritis, central nervous system diseases (described case gallyutsinatornogo syndrome). In appointing butadiona recommended limit Administration of sodium chloride in order to avoid delays and water development swells.
In appointing butadiona conjunction with other drugs is that it can detain for various drugs (amidopirina, morphine, PASK, penicillin, oral antidiabetics and anti-drugs, etc.) kidneys, help them accumulate in the body and can cause side effects.
Product : pills to 0.15 g.
The use of child practice also produces tablets of 0.03 and 0.05 g coated.
Storage : List B. The well ukuporennoy packaging keeps from the world.
Ointments butadionovaya. Contains 5% butadiona. Throm surface applied in the lower limbs, pneumonia gemorroidalnyh knots, with tendovaginitah Maze and others to cause a thin layer of skin area (not vtiraya) 2 - 3 times a day.
Product : in the box for 1920
Pills and amidopirina butadiona to 0,125 g-coated (Tabulettae Amidopyrini et Butadioni aa 0,125 on bductae).
Product : tablets, coated pinks; In a package of 10 pieces.
Similar pills are produced abroad under the title : Pirabutol, Reopirin, Alindor, Butapyrin, Irgapyrin, Pyrabutol, Reopyrin, Wolfapyrin.
When applied chamber, ishiase, lumbago, successfully, Rheumatoid polyarthritis, gouty arthritis, severe illness and other diseases involving inflammation phenomena.
Is the inside of one tablet 3 to 4 times a day.
Possible side effects and contraindications are the same as when applying butadiona.
Storage : List B. In dry dark place.
Due to limitations in the use of these combined regimen amidopirina amidopirina with butadionom (reopirin, pirabutol) have recently applied sparingly. Instead, they usually use more modern steroidal anti-inflammatory drug (ortofen, aspirin, etc.).
Reopirin : (Hungary) and pirabutol issued in ampoules containing 0.75 g sodium salt butadiona and 0.75 g amidopirina in 5 ml. Injections produced in the upper outer quadrant of gluteus muscles slowly (over 1 to 2 minutes). By injections used in the acute phase of illness. As a maintenance therapy, and in less serious cases appointed interior.
Injecting contraindicated with the use of a propensity to spazmofilii with heavy liver diseases, and epilepsy.
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