BRUNEOMITSIN (Bruneomycinum).

     Antibioticheskoe substance selected from the culture fluid tinomyces As a lbus v and r. bruneomycini. 5-Amino-6- (6-metoksi-5, 8-dihydro amino-5 - 8 dioksohinolil-2) -4 (2 - Oxy-3, 4-acid) -3 - metilpikolinovaya acid.

     Synonyms : Rufocromomycin, Streptonigrin.

     Bruneomitsin has cytostatic effect and oppressing development proliferiruyuschey tissue. Has expressed antitumor activity. In the framework of the preparation is important inhibition of DNA synthesis.

     Bruneomitsin (acid) is a crystalline powder brown nerastvorim water. Sodium salt bruneomitsina (for injection) - porous mass of brown, easily soluble in water; Solutions pH 7, 0, 7, 8.

     Bruneomitsin applied intravenously with chlamydia, retikulosarkome and lymphosarcoma, chronic lymphoblastic, Vilmsa tumors.

     Just before use, the contents of a bottle (0.5 mg bruneomitsina) dissolved in 20 ml isotonic sodium chloride solution. The drug is injected 200-400 µ g 2 - 3 times a week. At treated 2000-4000 ug.

     Children bruneomitsin give dose 5 - 10 µ g / kg 2 times a week. Dose rate is 40-60 µ g / kg. After 1, 2, 5-months can be renegotiated treatments, and reduce the dose in comparison with the first course of 25-50%.

     Bruneomitsin can be combined with other therapy drugs (tsiklofosfanom etc.), radiation therapy and corticosteroid.

     In applying bruneomitsina possible downgrading of appetite, nausea, vomiting, (it is more likely to occur when a single dose above 500 µ g). Lower doses of 200-400 ug avoids such reactions. At the end of the course can be a pain in the abdomen, diarrhea, stomatitis. To prevent disease and other fungal disease mucous membranes designate nystatin or levorin.

     Bruneomitsin may raise concerns leyko- and thrombocytopenia, with damaging effects on haematopoiesis may occur in 1 to 3 weeks after the last dose. Therefore, the drug has ceased to moderate leyko- and thrombocytopenia (with the number of leukocyte less than 4 x 10 9 / L and the number of platelets less than 120 x 10 9 / L). Blood tests conducted during and after treatment bruneomitsinom.

     Application bruneomitsina contraindicated with radiation (leukocyte levels below 4 x 10 9 / L) and thrombocytopenia (platelet level below 150 x 10 9 / L) of previous chemotherapy or radiation treatment, with the defeat of neoplastic bone marrow, disrupting kidney function (upgraded creatinine and urea in the blood).

     Enter strictly intravenously; When getting under the skin tissue necrosis is possible.

     Product : in vials containing 0.0005 g (500 ug) bruneomitsina injection <In runeomycinum pr on injectionibus) - mass brown, slightly soluble in water.

     Storage : List A. dry, the dark place at a temperature no higher than +20  C.

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