BROMOKRIPTIN (Bromocriptinum). 2-a-Brom- ergokriptin.

     Available in a mezilata (metansulfonata).

     Synonyms : Parlodel, Bromergon, Bromocriptinum mesilat, Parlodel, Pravidel.

     Parlodel Semi-derived alkaloid LPV - ergokriptina (see Derivative alkoloidov LPV). Is specific agonist dofamine receptors (mainly type D 2).

     Diluted actively influence the cycle start and noradrenalina in central nervous system, reducing the allocation of serotonin.

     Because of the stimulant dofamine receptors in the hypothalamus Parlodel has characterized the inhibitive effect on the secretion of pituitary hormones front, especially prolactin and somatotropina (See Drugs front of glands.) . Endogenous release is a physiological inhibitor of hormone secretions.

     Synthesis of prolactin Parlodel not violated. Inhibitive effect on the secretion of hormones removed dofamine receptors blockers (eg aminazinom).

     Parlodel (as Apomorphine, a stimulant D 2-receptors) has emetic effect, lowers the body temperature reduces akineziyu because rezerpinom, tetrabenazinom, fenotiazinovymi Neuroleptics. The drug has anti-hypertensive effects associated with the impact on the central nervous system, affects the sympathetic nerve roots and vascular smooth muscles. Impact on catecholamine content in the blood.

     Unlike ergometrina, metilergometrina and other similar drugs LPV (see), he has not had a "breeding" (oksitotsicheskogo) actions. Rather, it is depressing to reduce the uterus caused by metilergometrinom.

     Parlodel is used in obstetric and gynecological practice. In obstetrics drug is used to suppress lactation post when it vaccination (severe maternal illness, premature delivery, the newborn deaths, etc.). The use of the drug prevents breast-feeding, bloating and breast development yields mastita, restore ovarian function '.

     Assign product inside (in food) to 2, 5 mg (1 tablet) 2 times a day for 10 to 17 days. If necessary, treatment can be continued. Premature removal of the drug could lead to a resumption of lactation.

     Along with the end of lactation Parlodel is restoring menstrual cycle and helps pregnancies in women with giperprolaktinovoy amenorrhea.

     In gynecologic practice syndrome galaktorei - amenorrhea, razvivshemsya after birth, with violations functions : ovaries and infertility caused giperprolaktinemiey, and other diseases appoint 1, 25 mg (1 / 2 tablets) 2-3 times a day, by 2, 5 mg (1 tablet) 2 - 4 times a day. The course of treatment 3 to 6 months.

     Parlodel is also employed in galaktoree induced reception Neuroleptics (see), and other drugs (oral contraceptive drugs and so forth). Using as a preparation for the treatment of disease and akromegalii Itsenko - Kushinga.

     When illness Itsenko Kushinga-taking in the first days of July, 5 mg (3 tablets a day, then reduce the dose to 5-2, 5 mg (2 -1 tablet) per day. After 2-3 weeks designate supportive therapy for 2 , 5 mg (1 tablet) 1 every day. The course of treatment 6 to 8 months.

     In akromegalii appoint 5 to 10 mg per day. If necessary, increase the daily dose of 40 to 60 mg.

     In connection with agonisticheskim action at the D-2 receptors Parlodel also proposed for use in parkinsonizme (see Tools for treatment parkinsonizma). The effect is expressed, but in a moderate way, and there is the application of relatively high doses (30 and 40 mg / day) '.

     In applying bromokriptina and correctly selected doses, it is usually well tolerated. It absorbed quickly. Peak concentrations in plasma observed after 2 to 3 h after administration of the interior. Provided mainly with faeces, in small quantities in the urine.

     Possible adverse reactions are : nausea, sometimes vomiting, constipation, lower blood pressure (hypotension posturalnaya) pobelenie fingers and toes when cooled. Early treatment can headache, swelling of mucous membranes.

     The drug is not suitable for hypotension, recently transferred after myocardial infarction, and heart rhythm irregularities expressed in spastic conditions peripheral vascular, gastrointestinal tract diseases, mental illness.

     The drug has a sedative effect. His dolzhyy not take during those professions that require rapid physical and mental reactions (operators, drivers of cars, etc.).

     There should be appointed Parlodel in the first three months of pregnancy.

     Vast taking medication, should be under medical supervision. When treating bromokriptinom (parlodelom), the use of oral contraceptives.

     During treatment bromokriptinom not apply alkagolnye drinks. Do not take drugs, MAO inhibitors (see Antidepressant MAO-inhibitors) and preparations depressing central nervous system functions.

     Method of issuance : 2 tablets, 5 mg; Capsules of 5 or 10 mg.

     Storage : List B. In cool, the dark spot.

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