BONNEKOR (Bonnecor). 3-Karbetoksiamino-5- dimetilaminoatsetil-10, 11-dihydro-5 H-dibenzo [b, f] azepina hydrochloride.

     Synonyms : Tiratsizin, Tiracyzin.

     White or white with a yellowish sheen crystalline powder. Rastvo Rome in the water, it is difficult to alcohol.

     Bonnekor a new drug complications. On chemical structure it is similar to etmozinom but instead fenotiazinovogo cycle contains dibenzoazepinovy characteristic of the drugs antidepressan cent imipramina group (see Imipramin).

     The drug has antiaritmicheskoy activity. In the operation combines features complications drugs Groups I and IV. Along with each unit "fast" sodium channel antagonists possess properties of calcium ions.

     The drug is effective in parenteral and oral introduction. If ingestion is rapidly absorbed. Peak concentrations in plasma reaches is 1 to 1, 5 h, after which the concentration is declining rapidly. Period luvyvedeniya for about 2 hours; Continuing down metabolites 14-17 h.

     When applied nadzheludochkovyh and zheludochkovyh ekstrasistoliyah, couple ksizmalnoy nadzheludochkovoy tachycardia, focal zheludochkovyh tahikar respond to relapse prevention scintillation and predserdy fibrillation.

     In severe violations of rhythm (acute myocardial infarction) are chemicals inside a rate 0.3 - 0.6 mg / kg. Enter slowly in isotonic sodium chloride solution. Re-introduction of at least 6 hours

     Inside designate yes Z00 100 mg per day. Usually beginning with the admission of 50 mg, 2 times a day and, if necessary, increase the dose to 75 mg-100 2 - 3 times a day.

     Bonnekor generally well tolerated, does not diminish AD, it is uchasche a pulse. When intravenously, might be feeling heat, surrounded by naked, parestezii. Intravenous infusions would be held only in-patient elektrokardiograficheskim under control.

     The reception inside bonnekora could experience dry mouth, feeling numb mucous membranes of the oral cavity, diarrhoeal phenomenon. Possible allergic skin reaction.

     Sometimes there longer interval R-Q and development aritmogennogo effect.

     Pritivopokazaniya : expressed atrioventrikulyarnaya blockade, the embargo beam Guisa, expressed heart failure, kardiogenny shock, acute myocardial infarction period, pregnancy and lactation period.

     We should not impose solutions bonnekora patients with bronchial asthma (of the content in the capsules as a stabilizer sodium bisul veil). There should be appointed bonnekor odnovremenio with cardiac glycoside and enforced. Caution should be observed in liver function violations.

     Method of production : tablets of 50 mg and 100 in a package of 50 pieces; 0.5% solution in ampoules to 5 ml (25 mg) in a package of 10 pieces.

     Storage : List B. In the dark spot.

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