BETAKSOLOL (Betaxolol).

     1-[para-[2 - (Tsiklopropilmetoksi) ethyl] phenoxy] -3-[izopropilamino] -2-propanol.

     Synonyms : Betoptik, Lokren, Betoptic, Betoptima, Betoxolol, Kerione, Locren.

     The white crystalline powder. Mg in the water.

     Kardioselektivny? 1-adrenoblokator long periods. Has weak membranostabiliziruyuschim action. At London exchange is not affected.

     When administered quickly and almost completely absorbed, bioavailability of 80-90%, Cmax, 3-4 h, T? - 15-20 h; bad permeates through gisto- and gematicheskie barriers; kidney presented mostly in the form of metabolites.

     Applied as antihypertensive and antianginalnogo means inward, and to reduce the inner pressure of glaucoma eye drops (see Timolol).

     With arterial hypertension and strokes appointed interior, from 0.02 g (20 mg), 1 per day; If necessary, increase the daily dose through 7-14 days 0.04 g (40 mg).

     Antihypertensive effect develops in 2-3 h after administration, reaching a peak in 3-4 h and lasts 12-24 hours

     When glaucoma buried on one drop of 0.25% or 0.5% solution of 2 times a day.

     Possible side effects and contraindications are the same as the other? - Adrenoblokatorov (see Atenolol, Timolol).

     Antagonists of calcium ions, amiodarone, hinidinopodobnye drugs increase the risk of side effects of the cardiovascular system; NPVS, Glucocorticosteroids, mats and Antacids means weaken betaksolola antihypertensive effect.

     Method of production : tablets of 0.01 and 0.02 g (10 and 20 mg) (N. 14, 28); 0.25% Ophthalmic Suspension in vials of 5 and 10 ml and 0.5% solution (eye drops) in flakonah- looks to 5 ml.

     Storage : List B.

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