BENZOGEKSONY (Benzohexonium). 1, 6 - Bis (N-trimetilammony) - hexane dibenzolsulfonat.

     Synonyms : Geksony B, Hexamethonii Benzosulfonis.

     White or white with kremovatym nuance melkokristallichesky powder with weak as a smell. The easily soluble in water, dry in alcohol. Solutions to sterilize + 100 'C for 30 opinion.

     Instead dibenzolsulfonata may apply salt and 1, 6-bis (N trimetilammony) - hexane. Diyodid issued under the title "Geksony." Diyodidy and dibromidy produced abroad under the title : Bistrium, Gangliostat, Neha methonium, Neha m e ton, Neha nium, Neha thide, H i, the hex, thobromin Me, Me thonium, Vegolysen and others.

     Benzogeksony is symmetrical bischetvertichnym ammonium compounds with very strong ganglioblokiruyuschey activity.

     Applied with peripheral vascular spasm (endarteriit, peremezhayuschayasya limp, etc.), for edema PNDS crises in gastric ulcers and duodenal ulcers, with bronhiolospazmah to run hypotension. (For this purpose, preferably using korotkodeystvuyuschimi ganglioblokatorami (see Imehin)).

     Enter benzogeksony under the skin and inside intramuscularly, controlled hypotension drug injected. Doses to individualize, given the great variability among patients of different reactions to the drug (as well as to other ganglioblokiruyuschim substances).

     If you re-use a drug reaction to it gradually, which calls for increasing the dose. It is advisable to start treatment with lower doses, giving the desired effect, and then gradually increase the dose.

     The treatment of peripheral vascular spasm, ulcers, etc. recommends that the appointment of the drug inside (to food) in the dose of 0.1 g 3 6 times a day. With inadequate dose increased to 0.2 g / receptions or moving to a subcutaneous or intramuscular.

     To apply injecting 2, 5% solution. The average dose of subcutaneous or intramuscular introduction to the adult 0,025 g; Introducing 1 - 2 admission (1 to 0.5-2 ml, 5% solution). In gastric ulcer and duodenal ulcers should enter at 0.25 2 ml, 5% solution for 1 hour before meals four times a day.

     For edema PNDS crises impose intramuscularly or subcutaneously to 12, 5 to 25 mg (0.5 mL - 1, 2, 5% solution).

     If necessary benzogeksony can re-enter (3 to 4 injections per day).

     To treat hypertension benzogeksoniem (and other ganglioblokatorami) are now rare. But if used for this purpose usually combine it with saluretikami, apressinom antigipertenzivnymi or other drugs.

     To introduce controlled hypotension slowly intravenously (over 2 minutes) 1 - 1 5 2 ml, 5% solution; Effects develops within 12 to 15 minutes; If necessary, introduce additional amount of preparation.

     Higher doses for adults inside : single 0.3 g, 0.9 g daily; Under the Skin : single 0,075 grams daily 0.3 g.

     Treatment usually benzogeksoniem conduct courses for 2 - 4-6 weeks with a break between 1 to 3 weeks.

     Possible side effects : general weakness, dizziness, increased heart rate, dry mouth, midriaz, vascular injection Sclair. Contraindications : acute phase of myocardial infarction, expressed hypotension, eventually developed shock, kidney failure and liver, brain, central nervous system degenerative changes. Caution is needed in the appointment of the elderly.

     Method of issuance : pills to 0.1 g and 0.25 g; 2, 5% solution of 1 ml ampoules.

     Storage : List B. The well ukuporennoy packaging.

     R p. : Ta b. Ve nzohexonii 0.1 N. 20

     D.S. At one tablet three times a day

     R p. : S for l. Ve nzohexonii 2, 1 ml 5%

     D.t.d. N. 6 in a mpull.

     S. On January 1 ml under the skin once a day

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