AZITROMITSIN (Azithromycinum).

     Synonyms : Azivok, Azitroks, Azitrotsin, Zimaks, Zitrolid, Sumazid, Sumamed, Azitromycin, Azivok, Sumamed, Zimax.

     Antibiotics from the macrolides, dedicated a new subgroup azalidov.

     It is a semisynthetic derivative of erythromycin.

     It has a wide range of antimicrobial action. Vysokoeffektiven for a gram (staphylococci, streptococci, pnevmokokki), including produce? - Laktamazu, and gram (enterokokki, intestinal and Haemophilus wand gonokokki, legionelly, shigella, salmonella) microorganisms anaerobov (bakteroidy, receiver, peptokokki) , Chlamydia, and mycoplasms and spirohet.

     Compared with erythromycin active against gram microorganisms, more resistant to acid stomach, slowly out of the body and works longer; Better postponed; Less ingibiruet Cytochrome P-450 liver.

     In high concentrations has a bactericidal effect.

     Rapidly absorbed in the digestive tract (resistant to acid), bioavailability of approximately 37%, with max-2,5-3 h, T? - 14-68 h; well into the organs and tissues; microbicides concentration in the middle of an infectious inflammation supported within 5-7 days after the last dose; biotransformation exposed in the liver, bile appears mainly.

     Applied azithromycin of diseases caused by micro-organisms sensitive to it, including fatigue, pneumonia, bronchitis, pharyngitis, laringity, sinusitis, otites, scarlet fever, cobra, ugrevuyu rashes, chlamydial and gonococcal urethritis tservitsity, gonoreyny and negonoreyny Lyme (Lyme disease), with atypical bakteriozy AIDS and other infectious diseases.

     Using well as a comprehensive treatment of gastric ulcers and duodenal ulcers associated with Helicobacter pylori.

     Assign the interior (for 1 hour before or 2 hours after meals) is usually dependent on one 0.5 g once a day for 3 days or 1 day 0.5 g 1 every day, from 2 through 5 day-to 0.25 g 1 times a day; when Urogenital Diseases, 1 g once. Children over 12 months give one day to 10 mg / kg, then spent four days at 5 mg / kg one time a day.

     Possible allergic reactions, nausea, vomiting, cholestasis, jaundice.

     The drug is not suitable for violations expressed in liver function and kidney.

     Be wary nominated for heart arrhythmia.

     Method of issuance : pills to 0,125 grams (N. 6), and 0.5 g (N 3); Capsules of 0.25 g (N. 6); 2% and 4% (Fort) syrup; For granular powder 2% and 4% suspension for receiving inside for children in vials of 0.1 and 0.2 g; films (sterile towels) (0,3-0,5 g / g).

     In Russia registered with some other group of antibiotics, macrolides : Dzhozamitsin (Josamycin). Synonym : Vilprafen, Wilprafen. Diritromitsin (Dirithromycin). Synonyms : Dinabak, Dinabac.

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