AZATIOPRIN (Azathioprinum). 6 - (1-Metil-4- nitroimidazolil-5) - mercaptopurine.

      Synonyms: Imuran, a zamun, A zanin, A zapress, Imunal, Imuran, Imurel, T hio p rin e et al.

      Light yellow with a greenish white crystalline powder. Almost nerastvorim in water and alcohol, readily soluble in solutions caustic alkalis.

      On chemical structure and biological activities close to mercaptopurine. Has cytostatic activity and provides immunodepressivny effects, but compared to mercaptopurine immunodepressivnoe expressed a relatively greater in a lesser cytostatic activity. In high doses (10 mg / kg) product oppresses bone marrow function, and inhibits proliferation granulotsitov is radiation.

      Azathioprine applied to suppress the reaction of tissue incompatibility with organ transplants, as well as certain autoimmune diseases: rheumatoid polyarthritis non, non-ulcerative colitis, lupus red, volchanochnom nephritis, chronic hepatitis B and others.

      Assign product inside (in the form of tablets) alone, and often in conjunction with other tools (prednisolone, antibiotics, antileykotsitarnaya whey).

      In gomotransplantatsii authorities appointed before the surgery (1 -7 days) daily dose of 0,004 g / kg (4 mg / kg). The daily dose given in 2 -3 reception. Once the drug appointed to the same dose within 1 to 2 months, then to 2 to 3 mg / kg. In case of a transplanted organ rejection symptoms, the dose to increase to 4 mg / kg per day. Applied long preparation. The value of dose and duration of treatment depended on the total sostoniiya patient endurance drug, the results of blood research.

      In autoimmune diseases usually on 1, 5, 2, 0 mg / kg / day, but, if necessary, provide up to 200-250 mg / day (2 - 4 admission). The length of treatment depends on the severity of the disease, the effectiveness and acceptability of the drug. To achieve enduring effect of treatment should be extended.

      While the application of azathioprine in treating psoriasis (usually .05 g three times a day for 14-48 days).

      Treatment azathioprine to be carried out under close medical supervision. There is a need to monitor the blood picture.

      In the first 8 weeks of treatment should hold weekly analysis of blood platelets count.

      In reducing the number of leukocyte-4 * 10 9 / L dose reduced, but with 3 10 9 / L preparation cancel designate repeated blood transfusions, stimulants leykopoeza and others.

      The drug can cause nausea, vomiting, loss of appetite. With long-term use can develop chronic hepatitis; Possible allergic reactions.

      The drug is contraindicated in gemopoeza expressed oppression and radiation, severe liver diseases; Pregnancy.

      It should be noted that immune drugs can be very effective in the application to overcome the incompatibility tissue and treat autoimmune diseases. However, the current drugs do not have the selective action, and their use can be pronounced side effects. They may have a dampening vliyaie of blood and cause radiation, thrombocytopenia, anemia, pantsitopeniyu; Activation possible secondary infection, the development of septicemia. There are indications that long-term use may contribute to the development of malignant neoplasms immunosuppressants. There could also suppress the production of interferon, lowering the overall immune function.

      Immunosuppressants (cytostatics, including azathioprine, etc.) should apply strict condition with the necessary precautions.

 

      Product: pills to 0.05 g (50 mg) for 50 or 100 pieces in orange glass bottles.

      Storage: List A. In the dark spot.

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