AZAFEN (Azaphenum). 2 - (4-Metil-1- piperazinil) -10-methyl-3, 4-diazafenoksazina digidrohlorid.

     Synonyms : Azaksazin, Dizafen, Azaxazin, Dizaphenum, Pipofezinum.

     The crystalline powder yellowish - greenish color. The easily soluble in water, virtually nerastvorim in alcohol, p 1 N, 25% solution of 2, 5-3, 0.

     Azafen is original domestic antidepressant tritsiklicheskoy structure. On pharmacologically similar to imipraminu weakens deprimiruyuschie effects rezerpina, aggravating fenamina and 5-oksitriptofana but unlike imipramina (and amitriptyline) has holinoliticheskoy activity. MAO inhibition effect on the no. Timolepticheskoe combined with a sedative activity.

     Azafen has been in wide use in the treatment of depression.

     His appointed asteno- with anxiety and depressive state, manic depressive phase depressive psychosis involyutsionnoy melancholia, depression organic genesis, somatogenno of depression, reactive depression, repressive states, in developing long-term care Neuroleptics, and astenodepressivnyh able to eat nature. Can be used as a <<dolechivayuschego>> after treatment of other drugs.

     The drug is particularly effective with the depression of mild and severe; With profound depression can be used in combination with other tricyclic antidepressants. Azafen you can appoint, in conjunction with Neuroleptics.

     In connection with the reasonable, strong sedative and antidepressant activity of azafen widely used in diseases involving depressed and neurotic condition. There are performance azafena to treat depression in patients with coronary heart disease.

     Azafen successfully used to treat alcohol shallow depressions that form as a concern, and with inhibition.

     Assign azafen inside (after eating) in the 0,025-dose of 0.05 g (25-50 mg). Then gradually increase the dose to 25-50 mg / day (3 - 4 admission). Usually, the therapeutic dose of 0.15 - 0.2 grams per day. If necessary, increase the daily dose of up to 0.4 g. The course of treatment is continuing 1 - 1, 5 months. Upon reaching the therapeutic effect dose and gradually moved lower to supportive therapy (25-75 mg / day).

     Azafen usually well. Unlike imizina not cause schizophrenia in patients with acute symptoms of the problem (delirium, hallucinations), not increased anxiety and fear. The drug is sleep disturbance, and patients can take it in the evenings; Usually admission azafena improves sleep. The drug has no kardiatoksicheskimi properties. No side effects expressed by allowing for the preparation of patients with somatic diseases and the elderly.

     In the absence of holinoliticheskogo azafen can assign patients with glaucoma and other diseases in which the use of contraindicated drugs with holinoliticheskoy activity, including imipramina and amitriptyline.

     With regard to the reasonable azafen more convenient than imizin and other antidepressants for use in outpatient facilities.

     In some cases, admission azafena possible dizziness, nausea, vomiting; Smaller doses of these phenomena are rapidly.

     Azafen as drugs and other antidepressants should not be appointed with ingibatorami MAO. After these drugs azafen can designate 1 to 2 weeks.

     Product : pills to 0,025 g (25 mg) yellowish - greenish color in a package of 250 pieces.

     Storage : List B. In dry, the dark spot.

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