AZALEPTIN (Azaleptinum). 8-Chloro -11 - (4-methyl piperazinil) - 5 H-dibenzo [b, e] [1, 4] - diazepin.
Synonyms : Alemoksan, Clozapine, Leponeks, Alemoxan, Clazaril, Clozapine, Iprox, Lapenax, Leponex, Lepotex.
Melkokristallichesky greenish-yellow powder. Almost nerastvorim in water, soluble in alcohol difficult.
On the chemical structure of a compound drugs that are similarities with tricyclic antidepressants and partly benzodiazapine tranquilizers.
Has strong neurotic activity combined with sedatives properties.
Has muscle relaxing effect, potentsiruet of sleeping pills and analgetikov.
Typical pharmacological characteristics azaleptina are registered on electroencephalograms oppression reaction activation with superior electrical irritation formation of secondary brain expressed antiholinergicheskoe central and peripheral effects, a peripheral-adrenoliticheskoe effect; Preparation has kataleptogennym effect; There is a noticeable slowing release presinapticheskimi nerve endings.
Clinically is strong antipsychotic actions, combined with sedative component inherent in the absence of other neuroleptic extrapiramidale side effects (which may be connected with the central cholinolytic of preparation). There is a strong general oppression as aminazin and other aliphatic PHENOTHIAZINES.
When applied gallyutsinatorno- raving, katatono- gebefrennyh, katatonogallyutsinatornyh conditions and the state of psychomotor bringing in schizophrenia, with Manic syndrome in a manic depressive psychosis, with emotional tension and mood disorders, with a Psychopathy voz6 uzhdennyh patients. In some cases, medication is effective resistance to treatment with other doses.
Assign inside (after eating) 2 - 3 times a day. Under the dose for adults 50-100-200 mg; Daily doses of 200-400 mg; The maximum daily dose of 600 mg (0.6 g). For maintenance therapy and outpatient appoint 25-200 mg / day (in the form of a single dose taken in the evening hours). If necessary, introduce a solution azaleptina intramuscularly. In low doses (25-50 mg) product can be used in sleep disorders different genesis.
Azaleptin usually well; In view of the concerns expressed at the heart of cholinolytic and moderate impact on dofamine receptors is extrapiramidale violations. Nevertheless, the treatment azaleptinom could experience muscle weakness, drowsiness, sputannost consciousness, dry mouth, Orthostatic hypotension, tachycardia. The most serious oslozhenie - granulotsitopeniya (until agranulotsitoza). It is therefore necessary to closely monitor the blood picture. Blood tests during the first 16 weeks of treatment to every week, then at longer intervals. Prosecutors also for the state of the cardiovascular system.
The drug is contraindicated patient blood picture changes in alcohol and other toxic psychosis, spazmofilii, epilepsy, severe diseases of liver, kidney, cardiovascular, blood system diseases, glaucoma, the isolationist prostate gland, intestines atony, and pregnancy.
In connection with the possible sedative and sleeping pill effect should not appoint outpatient drug if they work requiring quick mental and physical reaction (transport drivers, etc.).
Method of issuance : azaleptin issued in the form of tablets of 25 mg and 100 greenish-yellow in a package of 50 pieces; Import drug leponeks produced, in addition, in the form of 2, 5% solution in ampoules to 2 ml (50 mg drug in vials) .
Storage : List B. In the dark spot.
Materials allowed to copy only with the active hyperlink to the handbook of medicines