CALCIUM salt (? R? R) -2 - (para-fluorophenyl )-?,?- dioksi-5- izopropil-3- fenil-4- (fenilkarbamoil) pirrolo-1- geptanoata.
Synonym : Liprimar, Liprimar.
A new (1990's.) Synthetic GMG- KoA- reductase inhibitor, referred to as the second generation of statins.
By chemically different from the "classic" statins group lovastatina and has similarities with fluvastatinom (includes ftorfenilny Radical and balance geptanoevoy acid).
Features of the drugs compared with other statins is a stronger lower level of cholesterol and triglycerides in LPNP serum, associated with longer GMG- KoA- reductase inhibition (20-30 h).
In the digestive tract absorbed quickly, bioavailability (relative) is 95-99%, S-max 1-2 h, T? 14-h; gall displayed.
Because of the special characteristics of a drug used to monotherapies in ateroskleroticheskih dislipidemiyah in cases not only isolated NCEP, but combined Moyle (including gipertriglitseridemii), and IBS with high cholesterol or total cholesterol LPNP.
Applied inside (regardless of the meal). Initial dose of 0.01 g (10 mg) 1 every day. Every four weeks determine lipid composition of the blood and, depending on the results refine the drug dose. The maximum daily intake - 0.08 g (80 mg). Effect develops over two weeks and reaches a maximum of 4 th week.
Like other lipid drugs, using drugs in the face of the drug free activities (diet, etc.) to reduce cholesterol levels.
The drug is usually well; May, however, neuralgia, headache, insomnia, fatigue, mialgiya, angionevrotichesky swelling, parestezii, peripheral neuropathy.
Contraindicated in acute liver diseases, pregnancy and breastfeeding.
Product : pills to 0.01; 0.02 and 0.04 g (N. 10, 30).
Materials allowed to copy only with the active hyperlink to the handbook of medicines