ASTEMIZOL (Astemizole) *. 1-(para-Ftorbenzil) -2-[1-(para-metoksifeniletil) -4 - piperidil] amino] benzimidazol.

     Synonyms : Gismanal, A lermizol, A stelong, ismanal N, N istamanal, Ifirab, L e mbil, Stemiz, Va gran.

     H-1 blockers gistaminovyh receptors.

     It binds to receptors dofamine muskarinovymi and has weak antiserotoninovoy activity. It has sedative action, not potentsiruet of hypnotics and sedatives, analgetikov.

     Characterized by a high intensity and duration of action. If ingestion is rapidly absorbed. Peak concentrations in plasma observed in 1 to 4 h after administration. Withdrawal from the body until 10 to 14 days.

     Partly unaltered astemizol and its metabolites are primarily from the faeces. After not penetrate the blood-brain barrier.

     Bioavailability astemizola reduced by dietary intake.

     Applied for the treatment of seasonal rinitov (pollinozov), allergic conjunctivitis, skin itching and other allergic symptoms.

     Assign adults and children over 12 years of age in the dose of 10 mg (0.01 g) 1 every day shock. If necessary, increase the daily dose of 30 mg. The maximum period of 7 days of receiving the drug.

     Children aged 6 to 12 years are to 5 mg per day (1 / 2 tablets); If necessary, and 15 mg / day, up to 7 days. Children under 6 years - 2 mg (2 ml suspension) to 10 kg of body weight.

     Before astemizola side effects are usually not seen, but may increase appetite increase body mass.

     When pregnancy drug is not appointed.

     Astemizol not affect the operation of corticosteroid, antibiotics, sulfanilamidov, diuretikov, analgetikov, cardiovascular drugs.

     Method of production : tablets of 0.01 g (10 mg) in a package of 10 pieces; Suspension containing 5 ml (1 teaspoonful) 0,005 g (5 mg) drug, in 50 ml vials.

     Storage : List B.

Materials allowed to copy only with the active hyperlink to the handbook of medicines