ARDUAN (Arduanum) *. 2, 16 b-bis (4-Dimetil-1- piperazino) 3-a, 17-b-diatsetoksi-5- a androstana dibromide.

     Synonyms : Pipekury bromide, Pipekurony bromide, Pipecuronii bromide, RGH 1106.

     Arduan is nedepolyarizuyuschim miorelaksantom. On chemical structure and action close to pankuroniyu (synonyms : Pavulon, ncuronium Ra, Ra n with uronii bromidum, avulon R), in recent years has been widely used as kurarepodobnogo drug. Both drugs are steroid compounds, but not hormonal activity. Kurarepodobny effect due to the presence of these two quaternary ammonium compounds (onievyh) groups from the optical distance between them, roughly equal distance between onievymi group of d-tubokurarina.

     Arduan an almost crystalline white powder, soluble in water and alcohol. Available in the form of freeze dry in capsules; Solutions substances in the 0.85% solution of sodium chloride transparent, colourless; PH 5, 0, 6, 5.

     In an experiment arduan has muscle relaxation effect in doses of 2 - 3-fold lower than doses pankuroniya, and a 2 times longer than pancuronium.

     Arduan in normal doses does not cause significant changes in the cardiovascular system. Only in high doses has weak ganglioblokiruyuschim actions; No release histamine.

     Miorelaksiruyuschee of arduana prozerinom removed.

     Arduan applied to the relaxation of muscles in a different type of surgical intervention, including operations on the heart, as well as obstetric care operations.

     Enter arduan intravenously. Heavy dose of 0,04 0,08 mg / kg. When dose 0.08 mg / kg ideal conditions for the surgical occur after 2 -3 minutes. For muscle relaxation in anaesthesia used drug in doses of 0.02 to 0.08 mg / kg `(often 0.04-0.05 mg / kg). If these doses are complete relaxation duration of about 50 minutes. If necessary lengthening effect using 1 / 4 of the initial dose. With insufficient kidney function should not be more than 0.04 mg / kg.

     Apply arduan can be different types of narcosis (ftorotanom, ether, nitrous oxide, etc.) required to endotrahealnoy surgical patient.

     Tiobarbituraty (tiopental- sodium) lengthened the time miorelaksatsii.

     The solution for injection are attached to the solvent just before use.

     If necessary, terminate arduana enter 1 to 3 mg prozerina after intravenous 0.25 - 0.5 mg atropine.

     The drug is contraindicated in infants and in the early stages of pregnancy. Caution is needed in violation of renal excretory function, because it partially allocated kidneys.

     Product : in ampoules containing 4 mg of the drug, adding solvent (4 ml vials) for the 50 vials of the drug and 50 vials of solvent.

     Storage : List A. In the refrigerator at 4 C.

     Est. Around the same doses that pancuronium (0.04 - 0.08 mg / kg). For activity (each dose causing complete miorelaksatsiyu) Both drugs significantly (5 to 10 times) than tubokurarin.

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