APROTININ (Aprotinin).

     SINONIMY : Gordoks, Ingiprol, Ingitril, Kontrikal, Pantripin, Trasilol, Traskolan, Contrical, Gordox, Ingiprolum, Ingitrilum, Pantrypinum, Trascolan, Trasylol.

     Antifermentny product obtained from the lungs or pancreas of cattle.

     Ingibiruet proteolytic enzymes (trypsin, himotripsin, kallikrein and plazmin) in plasma.

     Ingibiruya plazmin, fibrinoliticheskuyu activity lowers blood has gemostaticheskoe up at koalugopatiyah.

     Current data for acute pancreatitis is changing the process of pancreatic enzymes (trypsin, himotripsina, lipase, etc.). In physiological terms, these enzymes are iron in zimogennoy (inactive) form and activated only when in the intestines. Violation of metabolism and the emergence tsitokinazy (as a result of infection, trauma, lithogenesis, etc.) could lead to the allocation of streams in pancreatic enzymes activated, causing samoperevarivanie gland tissue, vnutritkanevye bleeding, swelling and other changes.

     Assign with acute and chronic pancreatitis, pankreonekroze, to prevent autoliza pancreas, with operations there and the number of bodies, if there is a risk of injury.

     Using also gaperfibrinoliticheshih krovotecheniyah giperplazminemii because, in open-heart operations using artificial blood.

     Possible side effects : arterial hypotension, tachycardia, nausea and vomiting (with the rapid introduction), bronchospasm, hallucinations, psychosis, allergic reactions, trombophlebitis place in the introduction.

Contraindications : syndrome disseminated vnutrisosudistogo closure (except giperkoagulyatsii phase), I and III trimenon, breast-feeding.

     Compatible with glyukokortikosteroidami and the infusion solutions containing amino acids and fat emulsion session; Lowers streptokinase activity, and urokinazy alteplazy.

     Pantripin (Pantrypinum). The drug Aprotinin, derived from the pancreas of cattle.

     Liofilizirovashshy yellowish powder. Ras do in the water.

     Activity pantripina determine biological method to reduce the ability of active trypsin. In 1 g product contains at least 650 ED.

     Applied for the treatment of acute pancreatitis and recidivism melt chronic pancreatitis, relapse prevention operations on the stomach and biliary tract, if there is a risk of injury pancreas.

     It should be borne in mind that in severe cases, the use of the drug is not a substitute for prompt intervention.

     Enter intravenously. In severe forms of pancreatitis are instantly 100-125 ED 10-20 ml of 5% glucose solution and isotonic sodium chloride solution. Then enter drip medication dose 25-30 ED in 500 ml of 5% glucose solution (with the addition of insulin at a rate of one for every ED 3-4 g glucose) or isotonic sodium chloride solution with the speed of 40-60 drops per minute. On the first day, you can re-enter up to a total dose of 250-300 ED. In the next day to enter ED 120-150 (depending on the picture of the disease). Introduction to repeat clinical recovery.

     In milder forms of the disease early dose of 12-25 ED, further establish dose depending on the condition of the patient (to introduce drip).

     In biliary, duodenalnyh, high intestinal fistula introduce drip on ED 1 6-12 times a day; Then change the dose, taking into account the clinical picture. Oseltamivir (with operations in the abdominal) Appoint 50-80 ED.

     The drug is also used in cataract removal operations using himotrinsina (see) for braking excess of enzyme imposed camera eyes. After 2-3 minutes after himotripsina in the front and back of the camera eye wash solution pantripina in isotonic sodium chloride solution.

     With caution should appoint people prone to allergic reactions. There is a need for careful monitoring of patients; Treatment should be under the control of amylase in blood and urine, with a measurement of body temperature. In preparation cancel events intolerances.

     FORM OUTPUT : powder for injection solutions in hermetically ukuporennyh bottles of 6 and 12 ED.

     STORAGE : dry, the dark place at a temperature no higher than 20 ° C.

     Ingitril (Ingitrilum). The drug Aprotinin obtained from the lungs of cattle.

     Liofinizirovanny powder cream or white with yellow shade of yellow color. The easily soluble in water and isotonic sodium chloride solution.

     Activity ingitrila determined to reduce the activity of trypsin and express in the ED. In 1 g product contains at least 550 ED.

     Applied for the treatment of acute pancreatitis, exacerbations of chronic pancreatitis and other evidence of a decline in active and fibrinoliticheskih proteolytic enzymes.

     Assign intravenous (struyno and drip) and place.

     In acute pancreatitis preferably drip a drug to ensure its smooth flow rate of 200 ED in the first day (the dose required to dissolve 500-1000 ml isotonic sodium chloride solution).

In complicated cases of acute pancreatitis Infusion ingitrila in the above dose of intravenously injecting concentrated solution (100 ED 10-20 ml isotonic sodium chloride solution). In the next 2-6 days preparation appointed to the same dose of ED-300, and the development of therapeutic effect can be reduced to 150-100 ED. After cupping pain, vomiting, removal of peritoneal events disappearance paresis bowel, ending tachycardia, normalization of amylase in blood and urine ingitril vzodyat bit of ED 60 per day for 3-4 days. If necessary to increase the dose to the ED 100-150 m / day treatment continued even 2-6 days. Admission drug stop, as soon as a permanent improvement. Heading ingitrila dose for the treatment of acute pancreatitis, ranging from 600 to 5000 ED.

     Patients, operated in an artificial blood product designated for the prevention and treatment fibrinoliticheskih bleeding, as well as pancreatitis, often complicating operations. Starting with slow inkjet of 100-200 ED ingitrila (10-20 ml isotonic sodium chloride solution), then to give intravenous drip for ED 200 a day during the first three days of postoperative period.

     When gastrointestinal and other krovotecheniyah involving fibrinolysis, designate drug dose intravenous drip in 300 ED day to Africa bleeding or blocked normalization fibrinoliticheskoy activity.

     When pancreatic and high tonkokishechnyh affects ingitril use local dose of 100 ED. In this case, dissolve themselves in isotonic solution of sodium chloride or other solvents (solutions novocaine, glucose), enough for around-the-clock slow drip of a fistula.

     Patients with Burns shock and severe burn toxaemia ingitril impose daily 140-200 ED intravenous drip at speeds of 40-60 drops per minute within 5-7 days. You may need dissolving dosage in 200 ml of 0.1% solution of novocaine,

     During treatment ingitrilom could experience allergic reactions in the form of urticaria, easily kupiruemoy antihistamines substances.

     The drug is contraindicated in cases involving high blood coagulation, and patients who have previously been neperenosimost ingitrila.

     FORM OUTPUT : powder for injection solutions ukuporennyh hermetically sealed bottles and 15 ED.

     STORAGE : dry, the dark place at a temperature no higher than 20 ° C.

     Kontrikal (Contrykal) *. The drug Aprotinin, close to the action on pantripinu.

     When applied krovotecheniyah of giperfibrinolizom, including after surgeries and injuries during and after birth, with complications in tromboliticheskoy therapy.

     Enter intravenous (slowly) struyno drip from the dose ED 350000, 149000 ED then every 4 hours until the hemostasis.

     When violations hemostasis initial dose of the birth of ED 700000, 140000 ED then at intervals of 1 h to stop bleeding.

     Children appoint 140000 ED / kg per day.

     Possible side effects : arterial hypotension, tachycardia, nausea, vomiting, allergic reactions, throm the site introduction.

     FORM OUTPUT : powder for injection solutions in vials and ampoules for ED 10000 (ATrE) together with the solvent (isotonic sodium chloride solution) in ampoules.

     STORAGE : in the dark place at a temperature no higher than 15 ° C.

     Gordoks (Gordox) *. The drug Aprotinin, derived from the glands podzheludochnyh butcher cattle.

     In action similar to pantripinom.

     Activity expressed kallikreinovyh inhibiting units (KIE); KIE was the number one drug, reduces by half the 2 ED kallikreina activity at pH 8.0.

     Indications for use like a pantripina and kontrikala,

     Enter curative to intravenous drip, starting with 500000 KIE, then a long drip Infusion estimated 50,000 KIE hour (or every 2-3 h 100000 KIE). As for improving the dose gradually reduced to 500,000 -300,000 KIE a day.

     For postoperative treatment and oseltamivir (with operations in the organs adjacent to the pancreas) originally imposed 200000 KIE, then, in the 1 st and 2 nd days after the operation, on 100000 KIE every 6 h (cefuroxim drip).

     In giperfibrinoliticheskih koagulopatiyah impose higher doses (KIE 1 million or more).

     In applying gordoksa, especially with a rapid injection can, nausea, allergic reactions. In such cases, stop the introduction of the drug. Individual sensitivity to gordoksu can be determined using the skin test (a 0.2 ml).

     Form of : injection of 10 ml ampoules (100000 KIE).

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