APROFEN (Aprophenum). (5 Dietilaminoetilovogo ester 1 1-difenilpropionovoy hydrochloride acid.

     Synonym : Ar about f r e num, Ar rofene.

     The white crystalline powder, readily soluble in water and alcohol. Aqueous solutions (pH 3, 7, 4, 7) in sterile 100 C over a period of 30 minutes.

     Has peripheral and central m and n-holinoliticheskoe effect. For peripheral holinoliticheskomu effect more active than spazmolitin. Has also spasmolytic effects. Expands coronary vessels, and in this respect it is more active than spazmolitin and papaverin. It is improving tone and greater reductions in the uterus.

     Applied with abdominal cramps (spastic colitis, cholecystitis, kidney and liver cramps, stomach ulcer disease) and vascular spasm (endarteriit, cramps brain vessels)

     In obstetric practice used to stimulate labor activity : while strengthening reduce uterine aprofen reduces causes Wrench sposostvuet and faster disclosure of the cervix in the first period of confinement.

     Assign inside after eating dose of 0,025 g 2 - 4 times a day; Under the skin or intramuscularly impose on 0.5 to 1 ml 1% solution.

     Higher doses for adults inside : single 0.03 g, 0.1 g daily; Under the skin and intramuscularly : single 0.02 grams daily 0.06 g.

     Possible complications and contraindications are the same as for spazmolitina.

     Method of issuance : powder; Pills to 0,025 g; 1% solution in 1 ml ampoules.

     Storage : List B. The well ukuporennoy packaging keeps from the world.

     Rp. : Tab. Days ropheni 0,025 N. 10

     D.S. At one pill 2 - 3 times a day (after eating)

     R p. : Sol. Apropheni 1% 1 ml

     D.t.d. N. 10 in a mpull.

     S. At 0.5 to 1 ml (under the skin or intramuscularly)

Materials allowed to copy only with the active hyperlink to the handbook of medicines