APRAKLODININ (Apraclonidine).

     2-[(4-Amino-2, 6-dihlorfenil) imino] imidazolidina hydrochloride.

     Synonym : Iopidin, Iopidine.

     The chemically different from clonidine only in the content of amino phenyl parameters of the kernel.

     Apraklonidin belongs to the group of stimulants (agonists)? 2-adrenoreceptor.

     Implemented (in the form of eye drops) to reduce the inner pressure in glaucoma (essentially reduces the secretion of moisture watery eyes). Unlike klofelina (clonidine) has expressed no systemic action : not change significantly the cardiovascular system has not demonstrated much sedative effect.

     Appointed mainly otkrutougolnoy glaucoma as an additional means of insufficient effectiveness of other drugs.

     Apply one drop of 0.5% solution 2-3 times a day. The effect after a single backfilling is within 1 h; Rush-through of 5-6 h.

     Possible side effects : allergic reactions (Blush close-itch, swelling), dry mouth; The elevated sensitivity probable violation coordinate movements adults.

     Note that in patients with glaucoma, has been using drugs, reduce the secretion of watery moisture (? - Adrenoblokatory, karboangidrazy inhibitors), the application apraklonidina reduce inner pressure sometimes it is because the mechanism of its action is also linked to the suppression of secretions.

     Product : 0.5% solution (eye drops) in 5 ml bottles. (Available as 1% solution for use in a segmented laser surgery.)

     Note. Apraklonidin established in the late 1980 - ies. In some countries (including the United States, France, etc.), it had already entered into medical practice, in other (eg, Russia) continues its in-depth clinical study.

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