ANGIOTENZINAMID (Angiotensinamidum).

     Angiotenzinamid issued for the medical use of the drug for injection (A ngiotensinamidum p r of eU tionibus inj), a L-asparaginil-L- arginil-L- valil-L- tirozil-L- valil-L gistidil-L- prolil-L- phenylalanine acetate.

     Synonyms : I-L- Asparagil-5-L- valilan- giotenzin II Gipertenzin, Nour rtensin.

     White powder derived from weak smell of acetic acid. The easily soluble in water, dry in alcohol.

     Angiotenzinamid pressornoe have a strong effect due to increased peripheral vascular resistance, especially arteriol small fire. At the tone veins affected slightly.

     Influenced angiotenzinamida particularly severe suzhivayutsya receptacles internal organs, skin, kidneys. Circulatory system in skeletal muscle and coronary vessels is not changing. Direct action on the heart medication and has no therapeutic doses witness is.

     The drug also has the ability to reduce uterine smooth muscles, digestive, urinary bladder and bubbles. It stimulates the designation of adrenaline glands and produce aldosterone.

     Angiotenzinamid quickly inaktiviruetsya enzymes in the blood, and therefore with a single to short (2 to 3 minutes) pressorny effect. However, the duration of effect can be relatively easy to manage, the speed of finding a solution drugs (intravenous drip).

     Applied in state of shock, especially when izovolemicheskom shock associated with vazomotornym collapse (after a serious personal shock, shock to intoxication, coma and infectious diseases as well as heart attacks, heart tamponade, massive pulmonary embolism, etc.). In kardiogennom shock, in cases involving konstriktornoy peripheral vascular response, the preparation must be applied with great caution (see Noradrenalin).

     Enter by slow intravenous drip Infusion.

     To dissolve dried angiotenzinamida use isotonic sodium chloride solution, or 5% solution glyunozy.

     Of the total quantity of solvent required for Infusion, gaining 10 ml syringe and enter through a rubber stopper in a bottle with angiotenzinamidom. The contents of a bottle carefully vzbaltyvayut until the dissolution of the powder. Then the solution in the syringe to transfer the remaining solvent.

     Because of the blood enzyme angiotenzinazy, medication should not be diluted blood serum and blood. Depending on the speed of a solution to the drug concentration of 1 to 50 µ g of 1 ml (for the slow introduction of low-concentration).

     For preparation of 1 µ g / ml bottle contents 1 (1 mg drug) dissolve in 1000 mL solvent, but the concentration of 50 µ g / ml in 20 ml solvent. Accordingly produce intermediate concentrations.

     The concentration of the solution and speed Infusion be collected so as to maintain systolic AD at 90-100 mm Hg. Art.

     Usually beginning with the introduction of the preparation of 5-20 µ g / min. In some severe cases Infusion speed of 50-60 µ g / min. When systolic AD 90-100 mm Hg. Art. speed Infusion reduced to 1 to 3 µ g / min.

     The drug could also be long-term (over many hours or several days), and should monitor kidney and liver function (the possibility of narrowing vessels).

     In applying angiotenzinamida possible aetiology, which kupiruetsya atropine.

     Angiotenzinamid contraindicated in gipovolemicheskom shock. Caution should be observed in patients with heart rhythm irregularities.

     Product : in the hermetically ukuporennyh bottles of 0,001 grams (1 mg) in a package of 40 pieces.

     Storage : List B. In cool, the dark spot.

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