ANASTROZOL (Anastrozole).

     ?,?,??,??- Tetrametil-5- (1 H-1, 2,4-triazol-1- mud methyl) - meta benzoldiatsetonitril.

     Synonym : Arimideks, Arimidex.

     The white crystalline powder. Poor soluble in water, soluble in methanol, ethanol and acetone, slightly soluble in acetonitrile.

     Lock making androgenov in estradiol (Tumor Cells in the breast) through selective inhibition Aromatase activity.

     If ingestion is well absorbed (up to 85%), C max was 2 h, T? 50-h; biotransformation are in the liver, kidneys predominantly displayed.

     When applied estrogenzavisimyh breast tumors in women postmenopauznom period.

     Assign the interior of 0,001 grams (1 mg), 1 per day.

     Possible side effects : diarrhoeal phenomenon, anorexia, Alopecia, arterial hypertension, trombophlebitis, mialgiya, arthralgia, anaemia, radiation, disturbances, allergic reactions.

     Contraindications : estrogennezavisimye tumors, disruption of the liver and kidney, pregnancy, breast-feeding.

     Product : pills to 0,001 g (1 mg) (N. 14, 28).

     Storage : List B.

Materials allowed to copy only with the active hyperlink to the handbook of medicines