AMRINON (Amrinone) *. 5-Amino [3 4'- bipiridin] -6 (1 H), he or Amino-5 (bipiridin-3, 4 ') (1 H) - on-6.

     Synonyms : Inocor, Wincoram (Some firms, entitled "In the main r" and also Nitrosorbid korazol.) .

     Amrinon is the first synthetic drug nesteroidnoy cardiac structure and neadrenergicheskoy Nature, found application in medical practice. The drug has a positive inotropnoe, and the effect of salts; In patients with congestive heart lacking accuracy Cardiac Output increases, decreases in pulmonary artery pressure and reduces peripheral vascular resistance.

     The drug is intended only for short-term treatment of acute congestive heart failure. Adequate experience amrinona has been acquired and appoint him to be ostorozhnostyo strictly followed the particular patient anxiety (Individual cardiac glycosides (digitoksin) used in the last century, and the optimal conditions for their use of refined for decades and amrinon and its analogues have only recently. ). Using the drug only in intensive care under the supervision of hemodynamics. Enter intravenously. Before the introduction of injectable solution amrinona grow in izotonicheskam solution of sodium chloride (but not glucose). Divorced solution can be stored no longer than 24 hours

     To obtain a rapid therapeutic effect imposed first by 0.5 mg / kg (bolyus) at about 1 mg per second. Then Injection (pain questions) in the dose of 0.5 to 1, 5 mg / kg at the same speed can be repeated at the interval with a 10 - 15 min. In the future hold Infusion of 5 to 10 µ g (0,005

     0.01 mg) for 1 kg of body weight per minute. The maximum total dose over the next first hour, equivalent to 4 mg / kg, usually enough to get out leg therapeutic effect.

     It is also possible to immediately continuous Infusion of ZO µ g / kg / min for 2 to 3 hours The speed of selecting individually for each patient. The total daily dose should not exceed 10 mg / kg.

     In applying amrinona possible hypotension, tachycardia, and ventricular nadzheludoch sophisticated detectors, a violation of kidney function, thrombocytopenia, as well as headache, gastrointestinal disorders, increased body temperature so.

     The drug can not be assigned to patients with contraindications to raise the heart of release : in obstructive cardiomyopathy, obstruk setting defeat heart valves, as well as acute gipovolemii, spouses ventrikulyarioy adults, anevrizme disorders, acute arterial hypotension, acute renal failure, thrombocytopenia. There is enough experience in amrinona tested in children and in adults with acute heart attack.

     Not sdeduet appoint preparation women in pregnancy and breastfeeding.

     Impose strict need intravenous fluids as possible angry surrounding tissue. The solution should not be confused amrinona races mixed with other medicines.

     Product : in 20 ml ampoules tank containing 100 mg amrinona, stabilizers and water for injection, in a package of 10 vials.

     Storage : List A. In the dark spot.

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