AMIRIDIN (Amiridinum). 9-Amino-2, 3, 5, 6, 7, 8-geksagidro-1H- tsiklopenta [b] hinolina hydrochloride, Monohydrate.

     Synonym : Ipidakrin, Ipidacrine.

     White melkokristallichssky powder. The easily soluble in water and alcohol.

     Is reversible cholinesterase inhibitors and has a characteristic of this group of drugs pharmacological effects. From conventional ingibitirov cholinesterase different, but that also induces a direct excitation of nerve fibers and synaptic transmission in neurotransmission end because of the blockade potassium channels vozbudimyh membranes.

     Amiridin aggravating to the smooth muscle not only acetylcholine, but also other substances mediator : adrenalin, serotonin, histamine, oxytocin.

     Indications for use mainly the same as for other drugs atsetilholinesteraznyh : neuritis, polinevrity, male and miastenicheskie syndrome, as well as chronic bulbarnye, appearances in organic defeat CNS accompanied by motor disorders. It can be used with atony ulcers and weak labor activity.

     Applied adults inside and parenteral. Inside appoint 0,01 - 0,02 g (10-20 mg) three times a day. Under the skin and intramuscularly, ranging from 5 to 15 mg (1 ml of 0.5% to 1 1 ml, 5% solution) 1 to 2 times a day. The course of treatment 1 - 2 months.

     For edema miastenicheskih crises impose dropped briefly to 1 1 - 2 ml, 5% solution (15 - 30 mg).

     Inside, with heavy violations neuro-muscular conductivity (in miastenicheskih crises) can be assigned to 1 - 2 tablets (0,02 - 0,04 g) to 5 to 6 times a day.

     For stimulation of labor activity inside designate one on one pill, but with little effect on 1 pill with double time interval.

     It also apply amiridin to reduce disturbance of memory in Alzheimer's disease (see Fizostigmin). Mechanism of action related to the stimulation of the central holinergicheskih processes. The efficiency and durability of the product (as well as the application of other anticholinesterase drugs) is not resolved [abroad than fizostigmina, studied in this aspect close to amiridinu structure ideystviyu drug takrin (Tacrin, Tenacrin) - hydrochloride 9-amino-1 , 2, 3, 4-tetragidroakridin].

     Possible side effects, contraindications and measures predostorozhnostn the same feature in primeneninii other anticholinesterase drugs (see Fizostigmin, Neostigmine, etc.).

     In overdose and individual sensitivity applied atropine or metacin.

     Method of issuance : 0,5 and 1%, 5% solutions in ampoules and 1 ml (5 and 15 mg vials in); Tablets of 0.02 g (20 mg) in a package of 50 pieces.

     Storage : List B. In the dark, dry place.

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